Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression

被引：17

作者：

Hiratsuka, T ^{[1
]}

Futagami, S ^{[1
]}

Shindo, T ^{[1
]}

Hamamoto, T ^{[1
]}

Ueki, N ^{[1
]}

Suzuki, K ^{[1
]}

Shinji, Y ^{[1
]}

Kusunoki, M ^{[1
]}

Shinoki, K ^{[1
]}

Wada, K ^{[1
]}

Miyake, K ^{[1
]}

Gudis, K ^{[1
]}

Tsukui, T ^{[1
]}

Sakamoto, C ^{[1
]}

机构：

[1] Nippon Med Coll, Dept Internal Med 3, Bunkyo Ku, Tokyo 1138603, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2005年 / 50卷 / Suppl 1期

关键词：

intercellular adhesion molecule-1; rebamipide; indomethacin; neutrophil;

D O I：

10.1007/s10620-005-2811-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) induced gastric mucosal injury occurs through subsequent events following free radical production derived from activated neutrophils. In this study, we hypothesized that rebamipide, a novel anti-ulcer agent, exerts a protective effect on NSAID-induced gastric injury through its antioxidant properties. The protective effect of rebamipide in a mouse model of indomethacin-induced gastric injury and mechanisms for this effect were investigated. Pretreatment with rebamipide significantly inhibited indomethacin-induced gastric mucosal injury in mice. Gastric thiobarbituric acid reactive substances (TBARS) levels and myeloperoxidase (MPO) activity substantially increased 3 hr after indomethacin administration. These increases were significantly inhibited by pre-treatment with rebamipide. Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM- 1) expression that was up-regulated in gastric tissue treated with indomethacin. Therefore, rebamipide may reduce indomethacin-induced gastric mucosal injuries through its antioxidant effect, which inhibits the neutrophil activation step following up-regulation of ICAM-1 expression on endothelial cells.

引用

页码：S84 / S89

页数：6

共 25 条

[1] Cyclo-oxygenase-2 regulates inducible ICAM-1 and VCAM-1 expression in human vascular smooth muscle cells [J].

Bishop-Bailey, D ;

Burke-Gaffney, A ;

Hellewell, PG ;

Pepper, JR ;

Mitchell, JA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 249 (01) :44-47

[2] The potentiating actions of cigarette smoking on ethanol-induced gastric mucosal damage in rats [J].

Chow, JYC ;

Ma, L ;

Zhu, M ;

Cho, CH .

GASTROENTEROLOGY, 1997, 113 (04) :1188-1197

[3]

ISHIHARA K, 1992, ARZNEIMITTEL-FORSCH, V42-2, P1462

[4] Cadmium stimulates the expression of ICAM-1 via NF-KB activation in cerebrovascular endothelial cells [J].

Jeong, EM ;

Moon, CH ;

Kim, CS ;

Lee, SH ;

Baik, EJ ;

Moon, CK ;

Jung, YS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 320 (03) :887-892

[5] Of blood and guts:: Association between Helicobacter pylori and the gastric microcirculation [J].

Kalia, N ;

Bardhan, KD .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2003, 18 (09) :1010-1017

[6] STIMULATION OF PROSTAGLANDIN BIOSYNTHESIS MEDIATES GASTROPROTECTIVE EFFECT OF REBAMIPIDE IN RATS [J].

KLEINE, A ;

KLUGE, S ;

PESKAR, BM .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (08) :1441-1449

[7]

KRAWISZ JE, 1984, GASTROENTEROLOGY, V87, P1344

[8]

Kwiecien S, 2003, J PHYSIOL PHARMACOL, V54, P423

[9]

LEE M, 1992, AM J PHYSIOL, V263, pG920

[10] Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats [J].

Murakami, K ;

Okajima, K ;

Uchiba, M ;

Harada, N ;

Johno, M ;

Okabe, H ;

Takatsuki, K .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (02) :319-325

← 1 2 3 →