Real-World Strategies to Treat Hypertension Associated with Pediatric Obesity

被引:10
作者
Binka, Edem [1 ]
Brady, Tammy M. [2 ]
机构
[1] Johns Hopkins Univ, Pediat Cardiol, Bloomberg Childrens Ctr, 1800 Orleans St,M2303, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Div Pediat Nephrol, David M Rubenstein Child Hlth Bldg,200 N Wolfe St, Baltimore, MD 21287 USA
基金
美国国家卫生研究院;
关键词
Obesity; Adiposity; Blood pressure; Hypertension; Cardiovascular disease risk factors; Weight management; Lifestyle modifications; Pharmacotherapy; SELECTIVE ALDOSTERONE BLOCKER; ADULT CARDIOVASCULAR-DISEASE; SCHOOL-AGED CHILDREN; BLOOD-PRESSURE; METABOLIC SYNDROME; PREVENTION; CHILDHOOD; HEALTH; SPIRONOLACTONE; ADOLESCENTS;
D O I
10.1007/s11906-019-0922-2
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Purpose of Review To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity. Recent Findings Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbingly, this rising prevalence has been paralleled by an increase in cardiovascular disease (CVD) risk factors in childhood such as hypertension, dyslipidemia, and diabetes that become manifest earlier than previously reported. These childhood CVD risk factors are not only associated with target organ damage in childhood but also track into adulthood, increasing the risk of long-term CVD morbidity and mortality. Summary There have been several mechanisms proposed to explain the role of obesity on the development of hypertension in childhood. However, central to the management of obesity-related hypertension is a multifaceted approach targeting lifestyle modifications and weight loss. Effective treatment often also requires a pharmacologic approach and rarely bariatric surgery.
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页数:8
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