Long-term management of canine disseminated granulomatous meningoencephalitis with imatinib mesylate: a case report

被引：1

作者：

Song, Joong Hyun ^{[1
]}

Hwang, Tae Sung ^{[1
]}

Lee, Hee Chun ^{[1
]}

Yu, Do Hyeon ^{[1
]}

Seung, Byung Joon ^{[2
]}

Sur, Jung Hyang ^{[2
]}

Jung, Dong In ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Coll Vet Med, Inst Anim Med, Jinju, South Korea

[2] Konkuk Univ, Coll Vet Med, Seoul, South Korea

来源：

VETERINARNI MEDICINA | 2019年 / 64卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

dog; immunohistochemical staining; magnetic resonance imaging; unknown aetiology; tyrosine kinase; tyrosine kinase inhibitor; NECROTIZING MENINGOENCEPHALITIS; HYDROXYUREA; DOGS; MODELS;

D O I：

10.17221/70/2018-VETMED

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A seven-year-old Toy Poodle was presented for progressive ataxia and seizure episodes. Magnetic resonance imaging revealed inflammatory lesions in the cerebrum and brainstem. Management with imatinib mesylate, prednisolone and hydroxyurea were initiated and resulted in complete resolution of the clinical signs. In regular magnetic resonance imaging scans, the overall appearance of the lesions deteriorated but improved again after an increase in the imatinib mesylate dose. The patient had not shown any neurological signs until death and survived for 1052 days after initial presentation. On histopathological examination, the patient was diagnosed with disseminated granulomatous meningoencephalitis involving the cerebrum and brainstem. Immunohistochemical staining was performed on the five types of tyrosine kinase (PDGFR-alpha, PDGFR-beta, VEGFR-2, c-Kit and c-Abl proteins), which constitute therapeutic targets for conventional multitargeted tyrosine kinase inhibitors. The immunohistochemical analysis revealed that all these tyrosine kinases were expressed in the brain samples. The present report describes the first case of the use of imatinib mesylate therapy for granulomatous meningoencephalitis in the dog. Therapy with imatinib mesylate plus glucocorticoids appears promising as a new therapeutic intervention in meningoencephalitis of unknown aetiology.

引用

页码：92 / 99

页数：8

共 25 条

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