Characteristics of non-obese non-alcoholic fatty liver disease: Effect of genetic and environmental factors

被引：60

作者：

Honda, Yasushi ^{[1
]}

Yoneda, Masato ^{[1
]}

Kessoku, Takaomi ^{[1
]}

Ogawa, Yuji ^{[1
]}

Tomeno, Wataru ^{[1
]}

Imajo, Kento ^{[1
]}

Mawatari, Hironori ^{[1
]}

Fujita, Koji ^{[1
]}

Hyogo, Hideyuki ^{[2
]}

Ueno, Takato ^{[4
]}

Chayama, Kazuaki ^{[3
]}

Saito, Satoru ^{[1
]}

Nakajima, Atsushi ^{[1
]}

Hotta, Kikuko ^{[5
]}

机构：

[1] Yokohama City Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Yokohama, Kanagawa, Japan

[2] JA Hiroshima Gen Hosp, Hiroshima, Japan

[3] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima, Japan

[4] Kurume Univ, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka, Japan

[5] Osaka Univ Hosp, Dept Med Innovat, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

HEPATOLOGY RESEARCH | 2016年 / 46卷 / 10期

关键词：

non-alcoholic fatty liver disease; non-obese non-alcoholic fatty liver disease; PNPLA3; type 2 diabetes mellitus; TRIGLYCERIDE TRANSFER PROTEIN; GENOME-WIDE ASSOCIATION; MORBIDLY OBESE PATIENTS; GASTRIC BYPASS-SURGERY; METABOLIC SYNDROME; PNPLA3; STEATOHEPATITIS; POLYMORPHISMS; POPULATION; PREVALENCE;

D O I：

10.1111/hepr.12648

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimThere are a considerable number of patients with non-obese non-alcoholic fatty liver disease (NAFLD). However, the clinical characteristics of non-obese NAFLD is not fully understood. We investigated genetic and other clinical parameters in non-obese and obese NAFLD. MethodsThe single nucleotide polymorphism rs738409 in the patatin-like phospholipase 3 gene (PNPLA3) was genotyped by the Invader assay in 540 NAFLD patients (134 non-obese and 406 obese) and 1012 control subjects (782 non-obese and 230 obese). All NAFLD patients underwent liver biopsy. Odds ratios were calculated by multiple logistic regression analysis using age, sex, body mass index (BMI), type 2 diabetes mellitus (T2DM) and rs738409 genotype as explanatory variables. ResultsNon-obese NAFLD subjects had a higher rs738409 GG genotype than obese NAFLD. Multiple logistic regression analysis indicated that the odds ratios of T2DM and rs738409 GG genotype for NAFLD were higher in non-obese than in obese groups. In non-obese NAFLD, rs738409 GG genotype was associated with lobular inflammation, hepatocyte ballooning and NAFLD activity score. In obese NAFLD, BMI and T2DM but not rs738409 GG genotype were associated with severity of histology. ConclusionWe demonstrated that the risk factors for the development and progression of NAFLD were different between non-obese and obese patients and that PNPLA3 rs738409 was strongly associated with the development and progression of non-obese NAFLD.

引用

页码：1011 / 1018

页数：8

共 46 条

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