An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

被引：1804
作者：
Saliminejad, Kioomars [1 ]
Khorshid, Hamid Reza Khorram [2 ]
Fard, Shahrzad Soleymani [1 ]
Ghaffari, Seyed Hamidollah [1 ]
机构：
[1] Univ Tehran Med Sci, Shariati Hosp, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran 1411713135, Iran
[2] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran, Iran
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 05期
关键词：
epigenetics; gene expression; intercellular communication; microRNA; therapeutics; DROPLET DIGITAL PCR; MEDIATED DOWN-REGULATION; MIRNA EXPRESSION; REFERENCE GENES; CANCER; RESOURCE; BIOGENESIS; LET-7; QUANTIFICATION; PROLIFERATION;
D O I：
10.1002/jcp.27486
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA-mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell-cell communication. In addition, alteration of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.
引用
收藏
页码：5451 / 5465
页数：15
相关论文
共 100 条
[91]  
Wang ZG, 2010, MICRORNA EXPRESSION DETECTION METHODS, P147, DOI 10.1007/978-3-642-04928-6_7
[92]   Mirtrons: microRNA biogenesis via splicing [J].
Westholm, Jakub O. ;
Lai, Eric C. .
BIOCHIMIE, 2011, 93 (11) :1897-1904
[93]   OncomiR: an online resource for exploring pan-cancer microRNA dysregulation [J].
Wong, Nathan W. ;
Chen, Yuhao ;
Chen, Shuai ;
Wang, Xiaowei .
BIOINFORMATICS, 2018, 34 (04) :713-715
[94]   Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4 [J].
Xiao, Qianren ;
Huang, Lu ;
Zhang, Zhongzu ;
Chen, Xiang ;
Luo, Jiaquan ;
Zhang, Zhanmin ;
Chen, Shaoqing ;
Shu, Yong ;
Han, Zhimin ;
Cao, Kai .
ONCOLOGY RESEARCH, 2017, 25 (02) :267-275
[95]   Universal Stem-Loop Primer Method for Screening and Quantification of MicroRNA [J].
Yang, Li-hong ;
Wang, Si-lu ;
Tang, Li-li ;
Liu, Biao ;
Ye, Wen-le ;
Wang, Ling-ling ;
Wang, Zhang-yang ;
Zhou, Meng-tao ;
Chen, Bi-cheng .
PLOS ONE, 2014, 9 (12)
[96]   The Potential Contribution of microRNAs in Anti-cancer Effects of Aurora Kinase Inhibitor (AZD1152-HQPA) [J].
Zekri, Ali ;
Mesbahi, Yashar ;
Boustanipour, Elham ;
Sadr, Zahra ;
Ghaffari, Seyed H. .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2018, 65 (04) :444-455
[97]   DNA Methylation Mediated Down-Regulation of miR-370 Regulates Cell Growth through Activation of the Wnt/β-Catenin Signaling Pathway in Human Osteosarcoma Cells [J].
Zhang, Wentao ;
Duan, Ning ;
Zhang, Qian ;
Song, Tao ;
Li, Zhong ;
Zhang, Caiguo ;
Chen, Xun ;
Wang, Kunzheng .
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017, 13 (05) :561-573
[98]   IsomiR Bank: a research resource for tracking IsomiRs [J].
Zhang, Yuanwei ;
Zang, Qiguang ;
Xu, Bo ;
Zheng, Wei ;
Ban, Rongjun ;
Zhang, Huan ;
Yang, Yifan ;
Hao, Qiaomei ;
Iqbal, Furhan ;
Li, Ao ;
Shi, Qinghua .
BIOINFORMATICS, 2016, 32 (13) :2069-2071
[99]   MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes [J].
Zhu, Youwei ;
Gu, Jiangning ;
Li, Ying ;
Peng, Chenghong ;
Shi, Minmin ;
Wang, Xuelong ;
Wei, Gang ;
Ge, Ouyang ;
Wang, Di ;
Zhang, Bosen ;
Wu, Jian ;
Zhong, Yiming ;
Shen, Baiyong ;
Chen, Hao .
CANCER LETTERS, 2018, 412 :59-68
[100]   Autoregulation of microRNA biogenesis by let-7 and Argonaute [J].
Zisoulis, Dimitrios G. ;
Kai, Zoya S. ;
Chang, Roger K. ;
Pasquinelli, Amy E. .
NATURE, 2012, 486 (7404) :541-U140
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