An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

被引：1780

作者：

Saliminejad, Kioomars ^{[1
]}

Khorshid, Hamid Reza Khorram ^{[2
]}

Fard, Shahrzad Soleymani ^{[1
]}

Ghaffari, Seyed Hamidollah ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Shariati Hosp, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran 1411713135, Iran

[2] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 05期

关键词：

epigenetics; gene expression; intercellular communication; microRNA; therapeutics; DROPLET DIGITAL PCR; MEDIATED DOWN-REGULATION; MIRNA EXPRESSION; REFERENCE GENES; CANCER; RESOURCE; BIOGENESIS; LET-7; QUANTIFICATION; PROLIFERATION;

D O I：

10.1002/jcp.27486

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA-mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell-cell communication. In addition, alteration of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.

引用

页码：5451 / 5465

页数：15

共 100 条

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