Helicobacter pylori Induction of Eosinophil Migration Is Mediated by the cag Pathogenicity Island via Microbial-Epithelial Interactions

被引：13

作者：

Nagy, Toni A. ^{[1
]}

Allen, Shannon S. ^{[1
]}

Wroblewski, Lydia E. ^{[1
]}

Flaherty, David K. ^{[2
]}

Slaughter, James C. ^{[3
]}

Perez-Perez, Guillermo ^{[4
]}

Israel, Dawn A. ^{[1
]}

Peek, Richard M., Jr. ^{[1
,5
]}

机构：

[1] Vanderbilt Univ, Sch Med, Div Gastroenterol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Med, Vanderbilt Vaccine Ctr, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37232 USA

[4] NYU, Sch Med, Dept Med, New York, NY USA

[5] Dept Vet Affairs Med Ctr, Nashville, TN 37212 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2011年 / 178卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CHRONIC GASTRITIS; CELLS; ACTIVATION; EXPRESSION; RECEPTOR; VACA;

D O I：

10.1016/j.ajpath.2010.12.018

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The host immune response directed against Helicobacter pylori is ineffective in eliminating the organism and strains harboring the cag pathogenicity island augment disease risk. Because eosinophils are a prominent component of H. pylori-induced gastritis, we investigated microbial and host mechanisms through which H. pylori regulates eosinophil migration. Our results indicate that H. pylori increases production of the chemokines CCL2, CCL5, and granulocyte-macrophage colony-stimulating factor by gastric epithelial cells and that these molecules induce eosinophil migration. These events are mediated by the cag pathogenicity island and by mitogen-activated protein kinases, suggesting that eosinophil migration orchestrated by H. pylori is regulated by a virulence-related locus. (Am J Pathol 2011, 178:1448-1452; DOI: 10.1016/j.ajpath.2010.12.018)

引用

页码：1448 / 1452

页数：5

共 14 条

[1] Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism [J].

Allison, Cody C. ;

Kufer, Thomas A. ;

Kremmer, Elisabeth ;

Kaparakis, Maria ;

Ferrero, Richard L. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (12) :8099-8109

[2] Functional association between the Helicobacter pylori virulence factors VacA and CagA [J].

Argent, Richard H. ;

Thomas, Rachael S. ;

Letley, Darren P. ;

Rittig, Michael G. ;

Hardie, Kim R. ;

Atherton, John C. .

JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (02) :145-150

[3] Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells [J].

Ding, Song-Ze ;

Olekhnovich, Igor N. ;

Cover, Timothy L. ;

Peek, Richard M., Jr. ;

Smith, Michael F., Jr. ;

Goldberg, Joanna B. .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2008, 53 (03) :385-394

[4] Helicobacter exploits integrin for type IV secretion and kinase activation [J].

Kwok, Terry ;

Zabler, Dana ;

Urman, Sylwia ;

Rohde, Manfred ;

Hartig, Roland ;

Wessler, Silja ;

Misselwitz, Rolf ;

Berger, Juergen ;

Sewald, Norbert ;

Koenig, Wolfgang ;

Backert, Steffen .

NATURE, 2007, 449 (7164) :862-U4

[5] Roles of Reactive Oxygen Species in CXCL8 and CCL2 Expression in Response to the 30-kDa Antigen of Mycobacterium tuberculosis [J].

Lee, Hye-Mi ;

Shin, Dong-Min ;

Kim, Kwang-Kyu ;

Lee, Ji-Sook ;

Paik, Tae-Hyun ;

Jo, Eun-Kyeong .

JOURNAL OF CLINICAL IMMUNOLOGY, 2009, 29 (01) :46-56

[6] EOSINOPHIL INFILTRATION AND DEGRANULATION IN HELICOBACTER-PYLORI-ASSOCIATED CHRONIC GASTRITIS [J].

MCGOVERN, TW ;

TALLEY, NJ ;

KEPHART, GM ;

CARPENTER, HA ;

GLEICH, GJ .

DIGESTIVE DISEASES AND SCIENCES, 1991, 36 (04) :435-440

[7] The role of mast cells and eosinophils in chronic gastritis [J].

Moorchung, N. ;

Srivastava, A. N. ;

Gupta, N. K. ;

Malaviya, A. K. ;

Achyut, B. R. ;

Mittal, B. .

CLINICAL AND EXPERIMENTAL MEDICINE, 2006, 6 (03) :107-114

[8] The role of myeloid cells in the promotion of tumour angiogenesis [J].

Murdoch, Craig ;

Muthana, Munitta ;

Coffelt, Seth B. ;

Lewis, Claire E. .

NATURE REVIEWS CANCER, 2008, 8 (08) :618-631

[9] Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor [J].

O'Brien, Daniel P. ;

Romero-Gallo, Judith ;

Schneider, Barbara G. ;

Chaturvedi, Rupesh ;

Delgado, Alberto ;

Harris, Elizabeth J. ;

Krishna, Uma ;

Ogden, Seth R. ;

Israel, Dawn A. ;

Wilson, Keith T. ;

Peek, Richard M., Jr. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (35) :23922-23930

[10] Helicobacter pylori and gastrointestinal tract adenocarcinomas [J].

Peek, RM ;

Blaser, MJ .

NATURE REVIEWS CANCER, 2002, 2 (01) :28-37

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