Asymmetric Mannich reactions catalyzed by cinchona alkaloid thiourea: enantioselective one-pot synthesis of novel β-amino ester derivatives

被引：38

作者：

Bai, Song ^{[1
]}

Liang, Xueping ^{[1
]}

Song, Baoan ^{[1
]}

Bhadury, Pinaki S. ^{[1
]}

Hu, Deyu ^{[1
]}

Yang, Song ^{[1
]}

机构：

[1] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2011年 / 22卷 / 05期

基金：

中国国家自然科学基金;

关键词：

AZA-HENRY REACTION; DYNAMIC KINETIC RESOLUTION; CHIRAL LEWIS-BASE; CONJUGATE ADDITION; STRECKER REACTION; N-BOC; BIFUNCTIONAL ORGANOCATALYSTS; STEREOSELECTIVE-SYNTHESIS; ACYL IMINES; KETO-ESTERS;

D O I：

10.1016/j.tetasy.2011.02.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient one-pot synthesis of novel beta-amino ester derivatives containing a benzoxazol moiety has been developed by using cinchona alkaloid thioureas as the organocatalyst. The adducts were isolated in high enantiomeric excess and high yield. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：518 / 523

页数：6

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