Hooked on zebrafish: insights into development and cancer of endocrine tissues

被引：11

作者：

Bourque, Caitlin

Houvras, Yariv ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Surg, New York, NY 10065 USA

来源：

基金：

美国国家卫生研究院;

关键词：

ZINC-FINGER NUCLEASES; ACUTE LYMPHOBLASTIC-LEUKEMIA; REGULATED TRANSGENIC ZEBRAFISH; CAUSES GENOME INSTABILITY; NERVE SHEATH TUMORS; T-CELL LEUKEMIA; THYROID-GLAND; PANCREAS DEVELOPMENT; DANIO-RERIO; INSERTIONAL MUTAGENESIS;

D O I：

10.1530/ERC-11-0099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Zebrafish is emerging as a unique model organism for studying cancer genetics and biology. For several decades zebrafish have been used to study vertebrate development, where they have made important contributions to understanding the specification and differentiation programs in many tissues. Recently, zebrafish studies have led to important insights into thyroid development, and have been used to model endocrine cancer. Zebrafish possess a unique set of attributes that make them amenable to forward and reverse genetic approaches. Zebrafish embryos develop rapidly and can be used to study specific cell lineages or the effects of chemicals on pathways or tissue development. In this review, we highlight the structure and function of endocrine organs in zebrafish and outline the major achievements in modeling cancer. Our goal is to familiarize readers with the zebrafish as a genetic model system and propose opportunities for endocrine cancer research in zebrafish.

引用

页码：R149 / R164

页数：16

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