In vivo assessment of emphysema in mice by high resolution X-ray microtomography

被引：41

作者：

Postnov, AA

Meurrens, K

Weiler, H

Van Dyck, D

Hu, X

Terpstra, P

De Clerck, NM

机构：

[1] Univ Antwerp, Dept Biomed Sci, B-2610 Antwerp, Belgium

[2] Univ Antwerp, Dept Phys, B-2610 Antwerp, Belgium

[3] PHILIP MORRIS Res Labs, B-3001 Louvain, Belgium

[4] PHILIP MORRIS Res Labs, D-51149 Cologne, Germany

来源：

JOURNAL OF MICROSCOPY | 2005年 / 220卷

关键词：

3D rendering; emphysema; in vivo scanning; X-ray microtomography;

D O I：

10.1111/j.1365-2818.2005.01510.x

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.

引用

页码：70 / 75

页数：6