Skin aging - Postulated mechanisms and consequent changes in structure and function

被引：106
作者：
Yaar, M [1 ]
Gilchrest, BA [1 ]
机构：
[1] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA
来源：
CLINICS IN GERIATRIC MEDICINE | 2001年 / 17卷 / 04期
关键词：
D O I：
10.1016/S0749-0690(05)70089-6
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is a complex process influenced by telomere shortening and damage to cellular DNA. New insights into age-associated decrements in DNA damage repair are reviewed. Age-associated gross, histologic, and functional cutaneous deficits are delineated. Different treatment options for aged skin are examined.
引用
收藏
页码：617 / +
页数：15
相关论文
共 75 条
[1]   TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].
ALLSOPP, RC ;
VAZIRI, H ;
PATTERSON, C ;
GOLDSTEIN, S ;
YOUNGLAI, EV ;
FUTCHER, AB ;
GREIDER, CW ;
HARLEY, CB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118
[2]  
Balin A K, 1989, Clin Geriatr Med, V5, P1
[3]  
BALIN AK, 1989, AGING SKIN
[4]  
BALLOU JA, 1989, ANTICANCER RES, V9, P1237
[5]   SYNDROMES OF PREMATURE AGING [J].
BEAUREGARD, S ;
GILCHREST, BA .
DERMATOLOGIC CLINICS, 1987, 5 (01) :109-121
[6]   PHOTOAGING VERSUS INTRINSIC AGING - A MORPHOLOGIC ASSESSMENT OF FACIAL SKIN [J].
BHAWAN, J ;
ANDERSEN, W ;
LEE, J ;
LABADIE, R ;
SOLARES, G .
JOURNAL OF CUTANEOUS PATHOLOGY, 1995, 22 (02) :154-159
[7]   STRUCTURE AND FUNCTION OF TELOMERES [J].
BLACKBURN, EH .
NATURE, 1991, 350 (6319) :569-573
[8]   Hormone replacement therapy and the skin [J].
Brincat, MP .
MATURITAS, 2000, 35 (02) :107-117
[9]   COLLAGEN-SYNTHESIS IN (SUN-)AGED HUMAN SKIN AND IN FIBROBLASTS DERIVED FROM SUN-EXPOSED AND SUN-PROTECTED BODY SITES [J].
BRINCKMANN, J ;
ACIL, Y ;
WOLFF, HH ;
MULLER, PK .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1995, 27 (01) :33-38
[10]   Role of cytoplasmic dynein in melanosome transport in human melanocytes [J].
Byers, HR ;
Yaar, M ;
Eller, MS ;
Jalbert, NL ;
Gilchrest, BA .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 114 (05) :990-997
12345678