Wnt signaling: multiple functions in neural development

被引：152

作者：

Ille, F ^{[1
]}

Sommer, L ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 10期

关键词：

Wnt signaling; beta-catenin; frizzled receptor; proliferation; apoptosis; stem cell maintenance; differentiation; lineage decision; axon guidance; neurite outgrowth;

D O I：

10.1007/s00018-005-4552-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signaling has proven to be essential for neural development at various stages and across species. Wnts are involved in morphogenesis and patterning, and their proliferation-promoting role is a key function in stem cell maintenance and the expansion of progenitor pools. Moreover, Wnt signaling is involved in differentiation processes and lineage decision events during both central and peripheral nervous system development. Additionally, several reports point to a role of Wnt signaling in axon guidance and neurite outgrowth. This article reviews and consolidates the existing evidence for the functions of Wnt signaling in neural development.

引用

页码：1100 / 1108

页数：9

共 112 条

[1] beta-catenin is a target for the ubiquitin-proteasome pathway
Aberle, H
Bauer, A
Stappert, J
Kispert, A
Kemler, R
[J]. EMBO JOURNAL, 1997, 16 (13) : 3797 - 3804
[2] Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
Adler, PN
Krasnow, RE
Liu, JC
[J]. CURRENT BIOLOGY, 1997, 7 (12) : 940 - 949
[3] Stem cells of the skin epithelium
Alonso, L
Fuchs, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 : 11830 - 11835
[4] A new member of the frizzled family from Drosophila functions as a Wingless receptor
Bhanot, P
Brink, M
Samos, CH
Hsieh, JC
Wang, YS
Macke, JP
Andrew, D
Nathans, J
Nusse, R
[J]. NATURE, 1996, 382 (6588) : 225 - 230
[5] Axon routing across the midline controlled by the Drosophila Derailed receptor
Bonkowsky, JL
Yoshikawa, S
O'Keefe, DD
Scully, AL
Thomas, JB
[J]. NATURE, 1999, 402 (6761) : 540 - 544
[6] Wnt signaling in breast cancer: have we come full circle?
Brown, AMC
[J]. BREAST CANCER RESEARCH, 2001, 3 (06): : 351 - 355
[7] Relationship of heart rate and oxygen uptake kinetics during deep water running in the adult population - Ages 50 to 70 years
Brown, SP
Jordan, JC
Chitwood, LF
Beason, KR
Alvarez, JG
Honea, KP
[J]. JOURNAL OF AGING AND PHYSICAL ACTIVITY, 1998, 6 (03) : 248 - 255
[8] Wnt signaling: a common theme in animal development
Cadigan, KM
Nusse, R
[J]. GENES & DEVELOPMENT, 1997, 11 (24) : 3286 - 3305
[9] The Wnt pathway, cell-cycle activation and β-amyloid:: novel therapeutic strategies in Alzheimer's disease?
Caricasole, A
Copani, A
Caruso, A
Caraci, F
Iacovelli, L
Sortino, MA
Terstappen, GC
Nicoletti, F
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (05) : 233 - 238
[10] Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway
Carron, C
Pascal, A
Djiane, A
Boucaut, JC
Shi, DL
Umbhauer, M
[J]. JOURNAL OF CELL SCIENCE, 2003, 116 (12) : 2541 - 2550

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