Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China

被引：58

作者：

Shen, M

Rothman, N

Berndt, SI

He, XZ

Yeager, M

Welch, R

Chanock, S

Caporaso, N

Lan, Q

机构：

[1] DHHS, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NCI,NIH, Bethesda, MD 20892 USA

[2] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

[3] NCI, CCR, DHHS, NIH, Bethesda, MD 20892 USA

来源：

LUNG CANCER | 2005年 / 49卷 / 03期

关键词：

folate metabolism; single nucleotide; polymorphism; lung cancer; polycyclic aromatic; hydrocarbon; haplotype;

D O I：

10.1016/j.lungcan.2005.04.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study is to investigate the role of genetic polymorphisms in twelve folate metabolism genes on the risk of Lung cancer in Xuan Wei, China, where the lung cancer mortality rate is among the highest and is mainly caused by indoor smoky coal emissions. A total of 122 incident primary lung cancer cases and 122 matched controls were enrolled. Three single nucleotide polymorphisms were associated with increased risk of Lung cancer including homozygotes of the C allele of CBS Ala360Ala (OR: 4.02; 95% CI: 1.64-9.87), the 222Val allele of MTHFR (OR: 2.32; 95% CI: 1.34-4.03), and the C allele of SLC19A1 Pro232Pro (OR: 1.83; 95% CI: 1.02-3.28). The distribution of CBS and MTHFR haplotypes differed between cases and controls (P=0.002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：299 / 309

页数：11

共 50 条

[21] LncRNA polymorphisms and lung cancer risk [J].

Abdi, Esmat ;

Latifi-Navid, Saeid ;

Panahi, Alireza ;

Latifi-Navid, Hamid .

PERSONALIZED MEDICINE, 2023, 20 (06) :511-521

[22] Polymorphisms in alternative splicing associated genes are associated with lung cancer risk in a Chinese population [J].

Shen, Wei ;

Yin, Rong ;

Wang, Cheng ;

Zhu, Meng ;

Zhou, Wen ;

Qin, Na ;

Sun, Jie ;

Liu, Jia ;

Dong, Jing ;

Jin, Guangfu ;

Ma, Hongxia ;

Hu, Zhibin ;

Shen, Hongbing ;

Xu, Lin ;

Dai, Juncheng .

LUNG CANCER, 2015, 89 (03) :238-242

[23] CHEMICAL CHARACTERIZATION OF INDOOR AIR OF HOMES FROM COMMUNES IN XUAN-WEI, CHINA, WITH HIGH LUNG-CANCER MORTALITY-RATE [J].

CHUANG, JC ;

CAO, SR ;

XIAN, YL ;

HARRIS, DB ;

MUMFORD, JL .

ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS, 1992, 26 (12) :2193-2201

[24] Polymorphisms in the Caspase7 gene and the risk of lung cancer [J].

Lee, Won Kee ;

Kim, Jong Sik ;

Kang, Hyo-Gyoung ;

Cha, Sung Ick ;

Kim, Dong Sun ;

Hyun, Dae Sung ;

Kam, Sin ;

Kim, Chang Ho ;

Jung, Tae Hoon ;

Park, Jae Yong .

LUNG CANCER, 2009, 65 (01) :19-24

[25] ATM polymorphisms and risk of lung cancer among never smokers [J].

Lo, Yen-Li ;

Hsiao, Chin-Fu ;

Jou, Yuh-Shan ;

Chang, Gee-Chen ;

Tsai, Ying-Huang ;

Su, Wu-Chou ;

Chen, Yuh-Min ;

Huang, Ming-Shyan ;

Chen, Hui-Ling ;

Yang, Pan-Chyr ;

Chen, Chien-Jen ;

Hsiung, Chao A. .

LUNG CANCER, 2010, 69 (02) :148-154

[26] Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population [J].

Park, Sun Ha ;

Choi, Jin Eun ;

Kim, Eun Jin ;

Jang, Jin Sung ;

Lee, Won Kee ;

Cha, Sung Ick ;

Kim, Chang Ho ;

Kam, Sin ;

Kim, Dong Sun ;

Park, Rang-Woon ;

Kim, Young-Chul ;

Han, Sung Beom ;

Jung, Tae Hoon ;

Park, Jae Yong .

LUNG CANCER, 2006, 54 (03) :303-308

[27] Polymorphisms of Genes Involved in the Folate Metabolic Pathway Impact the Occurrence of Unexplained Recurrent Pregnancy Loss [J].

Li Luo ;

Yueming Chen ;

Li Wang ;

Guangchao Zhuo ;

Chunning Qiu ;

Qiaofeng Tu ;

Jin Mei ;

Wen Zhang ;

Xia Qian ;

Xianjun Wang .

Reproductive Sciences, 2015, 22 :845-851

[28] Polymorphisms of Genes Involved in the Folate Metabolic Pathway Impact the Occurrence of Unexplained Recurrent Pregnancy Loss [J].

Luo, Li ;

Chen, Yueming ;

Wang, Li ;

Zhuo, Guangchao ;

Qiu, Chunning ;

Tu, Qiaofeng ;

Mei, Jin ;

Zhang, Wen ;

Qian, Xia ;

Wang, Xianjun .

REPRODUCTIVE SCIENCES, 2015, 22 (07) :845-851

[29] Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects [J].

Nakao, Haruhisa ;

Wakai, Kenji ;

Ishii, Norimitsu ;

Kobayashi, Yuji ;

Ito, Kiyoaki ;

Yoneda, Masashi ;

Mori, Mitsuru ;

Nojima, Masanori ;

Kimura, Yasutoshi ;

Endo, Takao ;

Matsuyama, Masato ;

Ishii, Hiroshi ;

Ueno, Makoto ;

Kuruma, Sawako ;

Egawa, Naoto ;

Matsuo, Keitaro ;

Hosono, Satoyo ;

Ohkawa, Shinichi ;

Nakamura, Kozue ;

Tamakoshi, Akiko ;

Takahashi, Mami ;

Shimada, Kazuaki ;

Nishiyama, Takeshi ;

Kikuchi, Shogo ;

Lin, Yingsong .

BMC GASTROENTEROLOGY, 2016, 16

[30] Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects [J].

Haruhisa Nakao ;

Kenji Wakai ;

Norimitsu Ishii ;

Yuji Kobayashi ;

Kiyoaki Ito ;

Masashi Yoneda ;

Mitsuru Mori ;

Masanori Nojima ;

Yasutoshi Kimura ;

Takao Endo ;

Masato Matsuyama ;

Hiroshi Ishii ;

Makoto Ueno ;

Sawako Kuruma ;

Naoto Egawa ;

Keitaro Matsuo ;

Satoyo Hosono ;

Shinichi Ohkawa ;

Kozue Nakamura ;

Akiko Tamakoshi ;

Mami Takahashi ;

Kazuaki Shimada ;

Takeshi Nishiyama ;

Shogo Kikuchi ;

Yingsong Lin .

BMC Gastroenterology, 16

← 1 2 3 4 5 →