Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

被引：55

作者：

Bezerra de Vasconcelos, Danielle Ingrid ^{[1
,2
]}

Leite, Jacqueline Alves ^{[1
]}

Carneiro, Luciana Teles ^{[1
]}

Piuvezam, Marcia Regina ^{[1
,2
]}

Vitorino de Lima, Maria Raquel ^{[1
]}

Lima de Morais, Liana Clebia ^{[1
]}

Rumjanek, Vivian Mary ^{[3
]}

Rodrigues-Mascarenhas, Sandra ^{[1
,2
]}

机构：

[1] Univ Fed Paraiba, Ctr Ciencias Saude, Dept Fisiol & Patol, Lab Tecnol Farmaceut, BR-58059900 Joao Pessoa, Paraiba, Brazil

[2] Univ Fed Paraiba, Dept Biol Mol, Ctr Ciencias Exatas & Nat, BR-58059900 Joao Pessoa, Paraiba, Brazil

[3] Univ Fed Rio de Janeiro, Inst Bioquim Med, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro, Brazil

来源：

MEDIATORS OF INFLAMMATION | 2011年 / 2011卷

关键词：

GROWTH-FACTOR RECEPTOR; ELEVATED PLUS-MAZE; LINK NA+/K+-ATPASE; HYDROALCOHOLIC EXTRACT; CYTOKINE PRODUCTION; HISTAMINE-RELEASE; ACETIC-ACID; MODULATION; INHIBITION; PLASMA;

D O I：

10.1155/2011/912925

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to modulate the immune response, little is known about the effect of this substance on the inflammatory process. The aim of this work was to study the effects triggered by ouabain on inflammation and nociceptive models. Ouabain produced a reduction in the mouse paw edema induced by carrageenan, compound 48/80 and zymosan. This anti-inflammatory potential might be related to the inhibition of prostaglandin E2, bradykinin, and mast-cell degranulation but not to histamine. Ouabain also modulated the inflammation induced by concanavalin A by inhibiting cell migration. Besides that, ouabain presented antinociceptive activity. Taken these data together, this work demonstrated, for the first time, that ouabain presented in vivo analgesic and anti-inflammatory effects.

引用

页码：1 / 11

页数：11

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