Transforming growth factor-β1 and disorders of the lung

被引:49
作者
Camoretti-Mercado, B [1 ]
Solway, A [1 ]
机构
[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA
关键词
asthma; chronic obstructive pulmonary disease; lymphangioleiomyomatosis; inflammation; cytokine; transforming growth factor-beta; emphysema; smooth muscle; tumor;
D O I
10.1385/CBB:43:1:131
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-beta subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-beta, specific and high-affinity binding to cell membrane serine/threonine kinase receptors, activation of intracellular cascades that include Smad molecules and mitogen-activated protein kinases, and regulated termination of the effect by diverse mechanisms including protein degradation and transcriptional activation. Several comprehensive reviews on TGF-beta biology in general and on the role of this cytokine in other diseases have been published recently. In recent years an unexpected role of TGF-beta on lung homeostasis has been revealed. Here, we discuss the contribution of TGF-beta to the pathogenesis of asthma and chronic obstructive pulmonary disease, two common illnesses of the lung, as well as of lymphangioleiomyomatosis, a rare disease in women. The information we collate and integrate places TGF-beta at a pivotal point within complex networks that control lung physiology as well as the physiopathology of these lung diseases.
引用
收藏
页码:131 / 148
页数:18
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