Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

被引：24

作者：

Cieluch, Aleksandra ^{[1
]}

Uruska, Aleksandra ^{[1
]}

Zozulinska-Ziolkiewicz, Dorota ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Internal Med & Diabetol, PL-60834 Poznan, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 08期

关键词：

mitochondrial dysfunction; diabetic cardiomyopathy; oxidative stress; OXIDATIVE STRESS; ATP SYNTHASE; HEART; INSULIN; OVEREXPRESSION; SUBPOPULATIONS; BIOENERGETICS; MITOFILIN; CATALASE; CHANNELS;

D O I：

10.3390/ijms21082852

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models have indicated the involvement of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy. In the current review, we aimed to collect scientific reports linking disorders in mitochondrial functioning with the development of diabetic cardiomyopathy in type 1 diabetes mellitus. We also aimed to present therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy in type 1 diabetes mellitus.

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页数：12

相关论文

共 40 条

[1] Mitochondrial KATP channels in cell survival and death [J].

Ardehali, H ;

O'Rourke, B .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 39 (01) :7-16

[2]

Bai JX, 2001, BIOL SIGNAL RECEPT, V10, P189

[3] Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase [J].

Baseler, Walter A. ;

Dabkowski, Erinne R. ;

Jagannathan, Rajaganapathi ;

Thapa, Dharendra ;

Nichols, Cody E. ;

Shepherd, Danielle L. ;

Croston, Tara L. ;

Powell, Matthew ;

Razunguzwa, Trust T. ;

Lewis, Sara E. ;

Schnell, David M. ;

Hollander, John M. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 304 (07) :R553-R565

[4] Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction [J].

Baseler, Walter A. ;

Dabkowski, Erinne R. ;

Williamson, Courtney L. ;

Croston, Tara L. ;

Thapa, Dharendra ;

Powell, Matthew J. ;

Razunguzwa, Trust T. ;

Hollander, John M. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2011, 300 (02) :R186-R200

[5] Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice [J].

Bugger, Heiko ;

Chen, Dong ;

Riehle, Christian ;

Soto, Jamie ;

Theobald, Heather A. ;

Hu, Xiao X. ;

Ganesan, Balasubramanian ;

Weimer, Bart C. ;

Abel, E. Dale .

DIABETES, 2009, 58 (09) :1986-1997

[6] Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation [J].

Chaban, Yuriy ;

Boekema, Egbert J. ;

Dudkina, Natalya V. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2014, 1837 (04) :418-426

[7] Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart [J].

Croston, Tara L. ;

Shepherd, Danielle L. ;

Thapa, Dharendra ;

Nichols, Cody E. ;

Lewis, Sara E. ;

Dabkowski, Erinne R. ;

Jagannathan, Rajaganapathi ;

Baseler, Walter A. ;

Hollander, John M. .

LIFE SCIENCES, 2013, 93 (08) :313-322

[8] Attenuation of Ca2+ homeostasis, oxidative stress, and mitochondrial dysfunctions in diabetic rat heart: insulin therapy or aerobic exercise? [J].

da Silva, Marcia F. ;

Natali, Antonio J. ;

da Silva, Edson ;

Gomes, Gilton J. ;

Teodoro, Bruno G. ;

Cunha, Daise N. Q. ;

Drummond, Lucas R. ;

Drummond, Filipe R. ;

Moura, Anselmo G. ;

Belfort, Felipe G. ;

de Oliveira, Alessandro ;

Maldonado, Izabel R. S. C. ;

Alberici, Luciane C. .

JOURNAL OF APPLIED PHYSIOLOGY, 2015, 119 (02) :148-156

[9] Role of Cardiolipin in Mitochondrial Signaling Pathways [J].

Dudek, Jan .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2017, 5

[10] Diabetes mellitus reduces the function and expression of ATP-dependent K+ channels in cardiac mitochondria [J].

Fancher, Ibra S. ;

Dick, Gregory M. ;

Hollander, John M. .

LIFE SCIENCES, 2013, 92 (11) :664-668

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