Directed γ-C(sp3)-H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis

被引：149
作者：
Chen, Dian-Feng [1 ]
Chu, Tjohn C. K. [2 ]
Rovis, Tomislav [1 ]
机构：
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
[2] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 42期
关键词：
N-H BONDS; C(SP(3))-H BONDS; ARYLATION; FUNCTIONALIZATION; RADICALS; OLEFINATION; ACTIVATION; AMINATION;
D O I：
10.1021/jacs.7b09306
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Visible light photoredox catalysis enables direct gamma- C(sp(3))-H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated in situ.
引用
收藏
页码：14897 / 14900
页数：4
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