Role of frontal white matter and corpus callosum on social function in schizophrenia

被引：47

作者：

Koshiyama, Daisuke ^{[1
]}

Fukunaga, Masaki ^{[2
]}

Okada, Naohiro ^{[1
,3
]}

Morita, Kentaro ^{[1
]}

Nemoto, Kiyotaka ^{[4
]}

Yamashita, Fumio ^{[5
]}

Yamamori, Hidenaga ^{[6
]}

Yasuda, Yuka ^{[6
]}

Fujimoto, Michiko ^{[6
]}

Kelly, Sinead ^{[7
,8
]}

Jahanshad, Neda ^{[7
]}

Kudo, Noriko ^{[9
]}

Azechi, Hirotsugu ^{[9
]}

Watanabe, Yoshiyuki ^{[10
]}

Donohoe, Gary ^{[11
]}

Thompson, Paul M. ^{[7
]}

Kasai, Kiyoto ^{[1
,3
]}

Hashimoto, Ryota ^{[6
,9
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Natl Inst Physiol Sci, Div Cerebral Integrat, Okazaki, Aichi, Japan

[3] Univ Tokyo, UTIAS, Int Res Ctr Neurointelligence WPI IRCN, Tokyo, Japan

[4] Univ Tsukuba, Fac Med, Dept Psychiat, Ibaraki, Japan

[5] Iwate Med Univ, Inst Biomed Sci, Div Ultrahigh Field MRI, Morioka, Iwate, Japan

[6] Osaka Univ, Dept Psychiat, Grad Sch Med, Osaka, Japan

[7] Univ Southern Calif, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Marina Del Rey, CA USA

[8] Harvard Med Sch, Boston, MA USA

[9] Osaka Univ, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev, Osaka, Japan

[10] Osaka Univ, Diagnost & Intervent Radiol, Grad Sch Med, Osaka, Japan

[11] Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom NICOG, NCBES Galway Neurosci Ctr, Coll Med Nursing & Hlth Sci,Clin Neuroimaging Lab, Galway, Ireland

来源：

SCHIZOPHRENIA RESEARCH | 2018年 / 202卷

基金：

日本学术振兴会;

关键词：

Diffusion tensor imaging (DTI); Anterior corona radiata; Fractional anisotropy (FA); Radial diffusivity (RD); Wechsler Adult Intelligence Scale-Third Edition (WAIS-III); University of California; San Diego Performance-Based Skills Assessment Brief (UPSA-B); SUBCORTICAL BRAIN VOLUME; PREFRONTAL CORTEX; NEUROCOGNITIVE DEFICITS; PICTURE ARRANGEMENT; COGNITIVE DEFICITS; GENETIC-ANALYSIS; LOBE PATHOLOGY; GRAY-MATTER; METAANALYSIS; SCALE;

D O I：

10.1016/j.schres.2018.07.009

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest. The fractional anisotropy (FA) in the anterior corona radiata and corpus callosum was significantly lower in patients than in HCS, and the radial diffusivity (RD) in the anterior corona radiata and corpus callosum was significantly higher in patients. The Picture Arrangement and Finance scores were both significantly impaired in patients. The effect of the FA of the right anterior corona radiata on the Finance score and the Picture Arrangement score, of the RD of the right anterior corona radiata on the Picture Arrangement score, and of the RD of the corpus callosum on the Picture Arrangement score were significant. In conclusion, our results confirmed the association between structural connectivity in the right frontal white matter and corpus callosum and social function in schizophrenia. These findings may provide a foundation for developing an intervention for functional recovery in schizophrenia. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：180 / 187

页数：8

共 54 条

[41] EnigmaVis: Online Interactive Visualization of Genome-Wide Association Studies of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium [J].

Novak, Nic M. ;

Stein, Jason L. ;

Medland, Sarah E. ;

Hibar, Derrek P. ;

Thompson, Paul M. ;

Toga, Arthur W. .

TWIN RESEARCH AND HUMAN GENETICS, 2012, 15 (03) :414-418

[42] Abnormal asymmetries in subcortical brain volume in schizophrenia [J].

Okada, N. ;

Fukunaga, M. ;

Yamashita, F. ;

Koshiyama, D. ;

Yamamori, H. ;

Ohi, K. ;

Yasuda, Y. ;

Fujimoto, M. ;

Watanabe, Y. ;

Yahata, N. ;

Nemoto, K. ;

Hibar, D. P. ;

van Erp, T. G. M. ;

Fujino, H. ;

Isobe, M. ;

Isomura, S. ;

Natsubori, T. ;

Narita, H. ;

Hashimoto, N. ;

Miyata, J. ;

Koike, S. ;

Takahashi, T. ;

Yamasue, H. ;

Matsuo, K. ;

Onitsuka, T. ;

Iidaka, T. ;

Kawasaki, Y. ;

Yoshimura, R. ;

Watanabe, Y. ;

Suzuki, M. ;

Turner, J. A. ;

Takeda, M. ;

Thompson, P. M. ;

Ozaki, N. ;

Kasai, K. ;

Hashimoto, R. .

MOLECULAR PSYCHIATRY, 2016, 21 (10) :1460-1466

[43] A meta-analysis of diffusion tensor imaging studies of the corpus callosum in schizophrenia [J].

Patel, Shivani ;

Mahon, Katie ;

Wellington, Robin ;

Zhang, Jianping ;

Chaplin, William ;

Szeszko, Philip R. .

SCHIZOPHRENIA RESEARCH, 2011, 129 (2-3) :149-155

[44] UCSD Performance-Based Skills Assessment: Development of a new measure of everyday functioning for severely mentally ill adults [J].

Patterson, TL ;

Goldman, S ;

McKibbin, CL ;

Hughs, T ;

Jeste, DV .

SCHIZOPHRENIA BULLETIN, 2001, 27 (02) :235-245

[45] Functional deficit of the medial prefrontal cortex during emotional sentence attribution in schizophrenia [J].

Razafimandimby, Annick ;

Herve, Pierre-Yves ;

Marzloff, Vincent ;

Brazo, Perrine ;

Tzourio-Mazoyer, Nathalie ;

Dollfus, Sonia .

SCHIZOPHRENIA RESEARCH, 2016, 178 (1-3) :86-93

[46] Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group [J].

Schmaal, L. ;

Veltman, D. J. ;

van Erp, T. G. M. ;

Saemann, P. G. ;

Frodl, T. ;

Jahanshad, N. ;

Loehrer, E. ;

Tiemeier, H. ;

Hofman, A. ;

Niessen, W. J. ;

Vernooij, M. W. ;

Ikram, M. A. ;

Wittfeld, K. ;

Grabe, H. J. ;

Block, A. ;

Hegenscheid, K. ;

Voelzke, H. ;

Hoehn, D. ;

Czisch, M. ;

Lagopoulos, J. ;

Hatton, S. N. ;

Hickie, I. B. ;

Goya-Maldonado, R. ;

Kraemer, B. ;

Gruber, O. ;

Couvy-Duchesne, B. ;

Renteria, M. E. ;

Strike, L. T. ;

Mills, N. T. ;

de Zubicaray, G. I. ;

McMahon, K. L. ;

Medland, S. E. ;

Martin, N. G. ;

Gillespie, N. A. ;

Wright, M. J. ;

Hall, G. B. ;

MacQueen, G. M. ;

Frey, E. M. ;

Carballedo, A. ;

van Velzen, L. S. ;

van Tol, M. J. ;

van der Wee, N. J. ;

Veer, I. M. ;

Walter, H. ;

Schnell, K. ;

Schramm, E. ;

Normann, C. ;

Schoepf, D. ;

Konrad, C. ;

Zurowski, B. .

MOLECULAR PSYCHIATRY, 2016, 21 (06) :806-812

[47] Involvement of the dorsolateral prefrontal cortex and superior temporal sulcus in impaired social perception in schizophrenia [J].

Shin, Jung Eun ;

Choi, Soo-Hee ;

Lee, Hyeongrae ;

Shin, Young Seok ;

Jang, Dong-Pyo ;

Kim, Jae-Jin .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2015, 58 :81-88

[48] Alterations in Brain Activation During Cognitive Empathy Are Related to Social Functioning in Schizophrenia [J].

Smith, Matthew J. ;

Schroeder, Matthew P. ;

Abram, Samantha V. ;

Goldman, Morris B. ;

Parrish, Todd B. ;

Wang, Xue ;

Derntl, Birgit ;

Habel, Ute ;

Decety, Jean ;

Reilly, James L. ;

Csernansky, John G. ;

Breiter, Hans C. .

SCHIZOPHRENIA BULLETIN, 2015, 41 (01) :211-222

[49] Limbic Interference During Social Action Planning in Schizophrenia [J].

Stegmayer, Katharina ;

Bohlhalter, Stephan ;

Vanbellingen, Tim ;

Federspiel, Andrea ;

Wiest, Roland ;

Mueri, Rene M. ;

Strik, Werner ;

Walther, Sebastian .

SCHIZOPHRENIA BULLETIN, 2018, 44 (02) :359-368

[50] Identification of common variants associated with human hippocampal and intracranial volumes [J].

Stein, Jason L. ;

Medland, Sarah E. ;

Vasquez, Alejandro Arias ;

Hibar, Derrek P. ;

Senstad, Rudy E. ;

Winkler, Anderson M. ;

Toro, Roberto ;

Appel, Katja ;

Bartecek, Richard ;

Bergmann, Orjan ;

Bernard, Manon ;

Brown, Andrew A. ;

Cannon, Dara M. ;

Chakravarty, M. Mallar ;

Christoforou, Andrea ;

Domin, Martin ;

Grimm, Oliver ;

Hollinshead, Marisa ;

Holmes, Avram J. ;

Homuth, Georg ;

Hottenga, Jouke-Jan ;

Langan, Camilla ;

Lopez, Lorna M. ;

Hansell, Narelle K. ;

Hwang, Kristy S. ;

Kim, Sungeun ;

Laje, Gonzalo ;

Lee, Phil H. ;

Liu, Xinmin ;

Loth, Eva ;

Lourdusamy, Anbarasu ;

Mattingsdal, Morten ;

Mohnke, Sebastian ;

Maniega, Susana Munoz ;

Nho, Kwangsik ;

Nugent, Allison C. ;

O'Brien, Carol ;

Papmeyer, Martina ;

Putz, Benno ;

Ramasamy, Adaikalavan ;

Rasmussen, Jerod ;

Rijpkema, Mark ;

Risacher, Shannon L. ;

Roddey, J. Cooper ;

Rose, Emma J. ;

Ryten, Mina ;

Shen, Li ;

Sprooten, Emma ;

Strengman, Eric ;

Teumer, Alexander .

NATURE GENETICS, 2012, 44 (05) :552-+

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