Solid phase synthesis of ultra-photostable cyanine NIR dye library

被引：25

作者：

Das, Raj Kumar ^{[1
,2
]}

Samanta, Animesh ^{[1
,2
]}

Ha, Hyung-Ho ^{[3
]}

Chang, Young-Tae ^{[1
,2
,4
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Inst Life Sci, Singapore 117543, Singapore

[2] Natl Univ Singapore, MedChem Program, Inst Life Sci, Singapore 117543, Singapore

[3] Sunchon Natl Univ, Coll Pharm, Sunchon 540742, South Korea

[4] ASTAR, Lab Bioimaging Probe Dev, Singapore Bioimaging Consortium, Singapore 138667, Singapore

来源：

RSC ADVANCES | 2011年 / 1卷 / 04期

关键词：

NEAR-INFRARED FLUOROCHROME; IN-VIVO; SUBSTITUENTS;

D O I：

10.1039/c1ra00498k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photostability is one of the key issues in NIR dyes and we have previously reported a photostable CyNA library. Herein we report an ultra-photostable cyanine-based NIR fluorescence library, CyR, utilizing the stability component of CyNA. Efficient solid phase chemistry was also devised to provide a robust synthetic route to the new library.

引用

页码：573 / 575

页数：3

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