Malignant peripheral nerve sheath tumor of the lower labial mucosa: case report and literature review

被引：5

作者：

do Amaral, Thiago Lucena ^{[1
]}

Valiati, Renato ^{[2
]}

Benevenuto de Andrade, Bruno Augusto ^{[1
]}

Pina, Alicia Rumayor ^{[3
]}

Torres, Sandra Regina ^{[1
]}

Romanach, Mario Jose ^{[1
]}

Agostini, Michelle ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, Rua Prof Rodolpho Paulo Rocco 325-1 Andar, BR-21941913 Rio De Janeiro, RJ, Brazil

[2] Univ Planalto Catarinense, Sch Dent, Lages, SC, Brazil

[3] Univ Estadual Campinas, Piracicaba Dent Sch FOP UNICAMP, Dept Oral Diag, Sao Paulo, Brazil

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2016年 / 122卷 / 02期

关键词：

HEAD; SCHWANNOMA; NECK; PATHOLOGY; FEATURES;

D O I：

10.1016/j.oooo.2015.11.009

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Malignant peripheral nerve sheath tumor (MPNST) is an uncommon soft tissue sarcoma with a predilection for the extremities and trunk of adults, rarely occurring in the oral cavity. To date, 10 cases of MPNSTs affecting the lower labial mucosa have been reported in the English language literature. We describe an additional case of MPNST in the lower labial mucosa of a 67-year-old male patient, who exhibited a painful swelling with a history of 4 months of evolution. Microscopic examination showed dense plexiform fascicles of spindle cells with wavy atypical nuclei. Mitotic figures and nuclear pleomorphism were evident. Immunohistochemical analysis of tumor cells revealed positivity for S-100 protein, CD56, CD34, and neuron-specific enolase but was negative for neurofilament protein, glut-1, claudin-1, desmin, and smooth muscle actin. Ki-67 labeling was 20%. The final diagnosis was MPNST. The lesion was surgically removed with wide margins, with no signs of recurrence after 4 years of follow-up.

引用

页码：E64 / E68

页数：5

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