Skeletal Muscle Atrophy and Degeneration in a Mouse Model of Traumatic Brain Injury

被引：18
作者：
Shahidi, Bahar [1 ]
Shah, Sameer B. [1 ]
Esparza, Mary [1 ]
Head, Brian P. [2 ]
Ward, Sam [1 ]
机构：
[1] Univ Calif San Diego, Dept Orthoped Surg, San Diego, CA 92103 USA
[2] Univ Calif San Diego, Dept Anesthesiol, San Diego, CA 92103 USA
来源：
JOURNAL OF NEUROTRAUMA | 2018年 / 35卷 / 02期
关键词：
atrophy; controlled cortical impact; degeneration; regeneration; skeletal muscle; traumatic brain injury; DENERVATION; CARDIOTOXIN; REGENERATION; MECHANISMS; SLOW;
D O I：
10.1089/neu.2017.5172
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Atrophy is thought to be a primary mode of muscle loss in neuromuscular injuries. The differential effects of central and peripheral injuries on atrophy and degeneration/regeneration in skeletal muscle tissue have not been well described. This study investigated skeletal muscle atrophy and degeneration/regeneration in an animal model of traumatic brain injury (TBI). Eight 8-month-old wild-type C57BL6 mice underwent either a sham craniotomy or TBI targeting the motor cortex. Atrophy (fiber area; FA) and degeneration/regeneration (centralized nuclei proportions; CN) of the soleus and tibialis anterior (TA) muscles were measured 2 months post-injury. Injured soleus FAs were smaller than sham soleus (p = 0.02) and injured TA (p < 0.001). Mean CNs were higher in the TBI-injured TA than in other muscles. Differential TBI-induced atrophy and degeneration/regeneration in lower limb muscles suggests that muscle responses to cortical injury involve more complex changes than those observed with simple disuse atrophy.
引用
收藏
页码：398 / 401
页数：4
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