Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

被引：10

作者：

Avino, Anna ^{[1
,2
,5
]}

Navarro, Isabel ^{[4
,5
]}

Farrera-Sinfreu, Josep ^{[3
]}

Royo, Miriam ^{[2
,3
]}

Aymami, Juan ^{[4
,7
]}

Delgado, Antonio ^{[6
,8
]}

Llebaria, Amadeu ^{[6
]}

Albericio, Fernando ^{[1
,2
,9
]}

Eritja, Ramon ^{[1
,2
,5
]}

机构：

[1] IRB Barcelona, Inst Biomed Res, E-08028 Barcelona, Spain

[2] CIBER BBN, Networking Ctr Bioengn Biomat & Nanomed, E-08028 Barcelona, Spain

[3] PCB, Combinatorial Chem Unit, E-08028 Barcelona, Spain

[4] Crystax Pharmaceut SL, E-08028 Barcelona, Spain

[5] CSIC, Spanish Res Council, Inst Adv Chem Catalonia, IQAC, E-08034 Barcelona, Spain

[6] CSIC, Spanish Res Council, Res Unit BioAct Mol, E-08034 Barcelona, Spain

[7] Univ Politecn Cataluna, Dept Engn Quim, E-08028 Barcelona, Spain

[8] Univ Barcelona, Fac Farm, CSIC, Unitat Associada,Unitat Quim Farmaceut, E-08028 Barcelona, Spain

[9] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 07期

关键词：

chromophore; fluorescence; oligonucleotides; solid-phase synthesis; phosphite-triester; DNA-intercalating drugs;

D O I：

10.1016/j.bmcl.2008.02.074

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2306 / 2310

页数：5

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