New prospective in treatment of Parkinson's disease: Studies on permeation of ropinirole through buccal mucosa

被引：36

作者：

De Caro, V. ^{[1
]}

Giandalia, G. ^{[1
]}

Siragusa, M. G. ^{[1
]}

Sutera, F. M. ^{[1
]}

Giannola, L. I. ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Sci & Tecnol Mol & Biomol STEMBIO, I-90123 Palermo, Italy

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 429卷 / 1-2期

关键词：

Buccal delivery; Ropinirole; Parkinson's disease; Absorption enhancement; Porcine buccal mucosa; TRANSDERMAL DELIVERY; PENETRATION; ENHANCERS; RELEASE; SYSTEM; MODEL;

D O I：

10.1016/j.ijpharm.2012.03.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic conditions. Ropinirole, widely used in treatment of motor fluctuations of Parkinson's disease, passes the buccal mucosa. Flux and permeability coefficient values suggested that the membrane does not appear a limiting step to the drug absorption. Nevertheless, an initial lag time is observed but the input rate can be modulated by permeation enhancement using limonene or by application of electric fields. Absorption improvement was accompanied by the important reduction of the lag time; at once the time required to reach the steady state plasma concentration was drastically decreased. On the basis of these results we could assume that clinical application of ropinirole by buccal delivery is feasible. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：78 / 83

页数：6

共 29 条

[1] Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease [J].

Ahlskog, J. Eric .

PHYSIOLOGY & BEHAVIOR, 2011, 104 (01) :168-172

[2] Oil based nanocarrier system for transdermal delivery of ropinirole: A mechanistic, pharmacokinetic and biochemical investigation [J].

Azeem, Adnan ;

Talegaonkar, Sushama ;

Negi, Lalit M. ;

Ahmad, Farhan J. ;

Khar, Roop K. ;

Iqbal, Zeenat .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 422 (1-2) :436-444

[3] Nanocarrier for the Transdermal Delivery of an Antiparkinsonian Drug [J].

Azeem, Adnan ;

Ahmad, Farhan J. ;

Khar, Roop K. ;

Talegaonkar, Sushama .

AAPS PHARMSCITECH, 2009, 10 (04) :1093-1103

[4] Human Buccal Mucosa as an Innovative Site of Drug Delivery [J].

Campisi, G. ;

Paderni, C. ;

Saccone, R. ;

Di Fede, O. ;

Wolff, A. ;

Giannola, L. I. .

CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (06) :641-652

[5] Pharmacokinetics of levodopa [J].

Contin, Manuela ;

Martinelli, Paolo .

JOURNAL OF NEUROLOGY, 2010, 257 :S253-S261

[6] Evaluation of galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: Part I [J].

De Caro, Viviana ;

Giandalia, Giulia ;

Siragusa, Maria Gabriella ;

Paderni, Carlo ;

Campisi, Giuseppina ;

Giannola, Libero Italo .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2008, 70 (03) :869-873

[7] Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue [J].

Del Consuelo, ID ;

Pizzolato, GP ;

Falson, F ;

Guy, RH ;

Jacques, Y .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2005, 94 (12) :2777-2788

[8] Buccal transport of flecainide and sotalol:: effect of a bile salt and ionization state [J].

Deneer, VHM ;

Drese, GB ;

Roemelé, PEH ;

Verhoef, JC ;

Lie-A-Huen, L ;

Kingma, JH ;

Brouwers, JRBJ ;

Junginger, HE .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 241 (01) :127-134

[9] About a synthetic saliva for in vitro studies [J].

Gal, JY ;

Fovet, Y ;

Adib-Yadzi, M .

TALANTA, 2001, 53 (06) :1103-1115

[10]

Giannola LI., 2008, PHARM TECH EUR, V20, P32

← 1 2 3 →