Citrate-capped Mn-modified CdSe/CdS quantum dots as luminescent probes for levodopa detection in aqueous solution

被引：31

作者：

Hu, Miao ^{[1
]}

Yu, Hailin ^{[1
]}

Wei, Fangdi ^{[1
]}

Xu, Guanhong ^{[1
]}

Yang, Jing ^{[1
]}

Cai, Zheng ^{[1
]}

Hu, Qin ^{[1
]}

机构：

[1] Nanjing Med Univ, Sch Pharm, Nanjing 210029, Jiangsu, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2012年 / 91卷

基金：

中国国家自然科学基金;

关键词：

CdSe/CdS; Mn; Levodopa; Fluorescence quenching; Probe; SEMICONDUCTOR NANOCRYSTALS; ULTRASENSITIVE DETECTION; FACILE SYNTHESIS; FLUORESCENCE; ELECTROPHORESIS; NANOPARTICLES; BENSERAZIDE; CARBIDOPA; TABLETS; ION;

D O I：

10.1016/j.saa.2012.01.081

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A novel kind of citrate capped Mn-modified CdSe/CdS quantum dots (QDs) was developed. The Mn-modified CdSe/CdS QDs had a narrow, symmetric emission and strong fluorescence with quantum yield over 41%. The interaction between the QDs and levodopa was investigated. The results showed that levodopa selectively quenched the fluorescence intensity of the QDs. Based on the fluorescence quenching of the synthesized QDs by levodopa, a simple, rapid and specific quantitative method for levodopa was proposed. The factors affecting the fluorescence detection for levodopa were studied. Under the optimum conditions, the quenched intensity of the fluorescence versus levodopa concentration from 1 to 100 mu M gave a linear response with an excellent correlation coefficient of 0.9996, and the limit of detection (3 sigma/K) was 2 x 10(-7) M. The contents of levodopa in pharmaceutical tablets were determined by the proposed method and the results agreed with the claimed values. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：130 / 135

页数：6

共 45 条

[1] Semiconductor nanocrystals as fluorescent biological labels [J].

Bruchez, M ;

Moronne, M ;

Gin, P ;

Weiss, S ;

Alivisatos, AP .

SCIENCE, 1998, 281 (5385) :2013-2016

[2] Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].

Chan, WCW ;

Nie, SM .

SCIENCE, 1998, 281 (5385) :2016-2018

[3] Potassium ion recognition by 15-crown-5 functionalized CdSe/ZnS quantum dots in H2O [J].

Chen, CY ;

Cheng, CT ;

Lai, CW ;

Wu, PW ;

Wu, KC ;

Chou, PT ;

Chou, YH ;

Chiu, HT .

CHEMICAL COMMUNICATIONS, 2006, (03) :263-265

[4]

Chen G, 1990, Method of fluorescent analysis, P2

[5] Facile synthesis of water-soluble and size-homogeneous cadmium selenide nanoparticles and their application as a long-wavelength fluorescent probe for detection of Hg(II) in aqueous solution [J].

Chen, Jinlong ;

Gao, YingChun ;

Guo, Chang ;

Wu, GenHua ;

Chen, YouCun ;

Lin, Biwen .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2008, 69 (02) :572-579

[6] A novel fluorescent array for mercury (II) ion in aqueous solution with functionalized cadmium selenide nanoclusters [J].

Chen, Jinlong ;

Gao, YingChun ;

Xu, ZhiBing ;

Wu, GenHua ;

Chen, YouCun ;

Zhu, ChangQing .

ANALYTICA CHIMICA ACTA, 2006, 577 (01) :77-84

[7] Functionalized semiconductor nanocrystals for ultrasensitive detection of peptides [J].

Chen, XD ;

Wang, XB ;

Liu, L ;

Yang, DC ;

Fan, L .

ANALYTICA CHIMICA ACTA, 2005, 542 (02) :144-150

[8] Water-soluble CdSe and CdSe/CdS nanocrystals: A greener synthetic route [J].

Deng, Da-Wei ;

Yu, Jun-Sheng ;

Pan, Yi .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2006, 299 (01) :225-232

[9] Facile Synthesis of Highly Luminescent UV-Blue-Emitting ZnSe/ZnS Core/Shell Nanocrystals in Aqueous Media [J].

Fang, Zheng ;

Li, Yan ;

Zhang, Hua ;

Zhong, Xinhua ;

Zhu, Linyong .

JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (32) :14145-14150

[10] Surface-modified CdSe quantum dots for the sensitive and selective determination of Cu(II) in aqueous solutions by luminescent measurements [J].

Fernández-Argüelles, MT ;

Jin, WJ ;

Costa-Fernández, JM ;

Pereiro, R ;

Sanz-Medel, A .

ANALYTICA CHIMICA ACTA, 2005, 549 (1-2) :20-25

← 1 2 3 4 5 →