MEASUREMENT AND PREDICTION OF BINARY AND TERNARY LIQUID-SOLID EQUILIBRIA OF PHARMACEUTICAL AND FOOD SYSTEMS

Solid-liquid equilibria are imperatively required for any design calculations of equipments like crystallizers. Since any experimental measurement is not always easy to carry out, then the modeling of such data can be of a great importance. Consequently the present work deals with measurements by means of the differential scanning calorimetry (DSC) technique, and then predictions of solid-liquid equilibria in order to calculate the necessary interaction parameters for thermodynamic activity coefficient models like the UNIFAC or the NRTL. Binary and ternary systems which may have applications in the food or the pharmaceutical fields, were considered in the present study, with water or formamide as the solvents and D-Sorbitol, D-Glucose and D-Glucose monohydrate, as the solid solute. (C) 2012 Published by Elsevier Ltd. Selection and/or peer review under responsibility of The TerraGreen Society.