Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract

被引：0

作者：

Serafini, Mairim Russo ^{[1
]}

de Lima, Claudio Moreira ^{[1
]}

Santos, Rodrigo Correia ^{[1
]}

Azevedo Doria, Grace Anne ^{[1
]}

de Jesus, Josepha Yohanna ^{[1
]}

Doria de Melo, Marcelia Garcez ^{[1
]}

Almeida dos Santos, Joao Paulo ^{[1
]}

Rabelo, Thallita Kelly ^{[1
]}

Fortes, Vanessa Silveira ^{[2
]}

Vieira Fonseca, Maria Jose ^{[2
]}

de Albuquerque, Ricardo Luiz Cavalcanti, Jr. ^{[3
]}

Quintans-Junior, Lucindo Jose ^{[3
]}

de Souza Araujo, Adriano Antunes ^{[1
]}

机构：

[1] Univ Fed Sergipe, Dept Fisiol, Sao Cristovao, Sergipe, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil

[3] Univ Tiradentes, Aracaju, Sergipe, Brazil

来源：

AFRICAN JOURNAL OF BIOTECHNOLOGY | 2011年 / 10卷 / 65期

关键词：

Morinda citrifolia; cytotoxicity; acute toxicity; MEIC CHEMICALS; CYTOTOXICITY; ASSAYS; NONI;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This investigation was carried out to evaluate the safety of an aqueous extract of Morinda citrifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14 days. Biochemical and hematological parameters were determined after 14 days. Cytotoxic effects of the AEMC were determined by spectrophotometric 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (at concentration of 0.05 to 25 mg/ml). The results showed that in the acute study in rats, the AEMC did not cause general behavior adverse effects and mortality. Also, AEMC did not show any cytotoxic effect at 0.05 to 12.5 mg/ml, only at 25 mg/ml. The AEMC does not appear to have significant toxicity.

引用

页码：14566 / 14572

页数：7

共 50 条

[1] Anti-proliferative activity of Thai Noni (Morinda citrifolia linn.) leaf extract
Thani, W.
Luanratana, O.
Siripong, P.
Ruangwises, N.
PLANTA MEDICA, 2008, 74 (09) : 970 - 970
[2] Identification of major aroma compounds in the leaf of Morinda citrifolia Linn.
Brett J. West
Bing-nan Zhou
Journal of Natural Medicines, 2008, 62 : 485 - 487
[3] PROTECTION AGAINST SODIUM ARSENITE -INDUCED TOXICITY IN RATS BY NONI EXTRACT (MORINDA CITRIFOLIA LINN.)
Ola-Davies, Olufunke E.
Adeogun, Aina O.
Opasina, Oladayo F.
DRUG METABOLISM REVIEWS, 2014, 45 : 122 - 122
[4] Effect of Morinda citrifolia Linn. Leaf Extracts on in vitro Lipase Activity
Saraphanchotiwitthaya, Aurasorn
Sripalakit, Pattana
CHIANG MAI JOURNAL OF SCIENCE, 2014, 41 (5.1): : 1182 - 1193
[5] Evaluation of anti-genotoxicity of the leaf extracts of Morinda citrifolia Linn.
Sreeranjini, S.
Siril, E. A.
PLANT SOIL AND ENVIRONMENT, 2011, 57 (05) : 222 - 227
[6] ANTI-PROLIFERATIVE AND ANTIOXIDATTVE ACTIVITIES OF THAI NONI/YOR (MORINDA CITRIFOLIA LINN.) LEAF EXTRACT
Thani, Wasina
Vallisuta, Omboon
Siripong, Pongpan
Ruangwises, Nongluck
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, 2010, 41 (02) : 482 - 489
[7] Morinda citrifolia Linn. fruit extract mitigates heroin seeking behavior in mice
Pandy, Vijayapandi
Khan, Yasmin
Yarlagadda, Durga Priyanka
Tatinada, Sri Pravallika
ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2021, 81 (04) : 328 - 334
[8] Pre-clinical toxicity evaluation of leaf-stalk extractive of Piper betle Linn. in rodents
Sengupta, Amitabha
Adhikary, Purnima
Basak, Bidyut Kumar
Chakrabarti, Kaushiki
Gangopadhyay, Paramita
Banerji, Julie
Chatterjee, Asima
Indian Journal of Experimental Biology, 2000, 38 (04) : 338 - 342
[9] Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema
Brett J. West
Shixin Deng
Afa K. Palu
C. Jarakae Jensen
Journal of Natural Medicines, 2009, 63 : 351 - 354
[10] Methanol Extract of the Fruits of Morinda citrifolia Linn., Restores Bone Loss in Ovariectomized Rats
Shirwaikar, A.
Kamariya, Y.
Patel, B.
Nanda, S.
Parmar, V.
Khan, S.
INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2011, 7 (04) : 446 - 454

← 1 2 3 4 5 →