Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens

被引：57
|
作者：
Reiss, Stephan [1 ,2 ]
Burau, Gerolf [1 ]
Stachs, Oliver [2 ]
Guthoff, Rudolf [2 ]
Stolz, Heinrich [1 ]
机构：
[1] Univ Rostock, Semicond Opt Grp, Inst Phys, D-18055 Rostock, Germany
[2] Univ Rostock, Ophthalmol Clin, Fac Med, D-18055 Rostock, Germany
来源：
BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 08期
关键词：
REFRACTIVE-INDEX DISTRIBUTION; CRYSTALLINE LENS; ELASTIC PROPERTIES; IN-VIVO; SCATTERING; ACCOMMODATION; AGE; PRESBYOPIA; MICROSCOPY; CONSTANTS;
D O I：
10.1364/BOE.2.002144
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Presbyopia is closely associated with the loss of accommodation, and hence with a decline in the viscoelastic properties of the human eye lens. In this article we describe a method for obtaining spatially resolved in vivo measurements of the rheological properties of the eye lens, based on the spectroscopic analysis of spontaneous Brillouin scattering using a virtually imaged phased array (VIPA). The multi-pass configuration enhances resolution to the extent that measurements are possible in elastic biological tissue characterized by intense scattering. We also present spatially resolved measurements obtained in extracted animal eyes and lenses. The results yield entirely new insights into the aging process of the eye lens. (C) 2011 Optical Society of America
引用
收藏
页码：2144 / 2159
页数：16
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