Synthesis of Water-Soluble Prodrug of Florfenicol

被引：0

作者：

Qin, G. C. ^{[2
]}

Chen, L. X. ^{[2
]}

Yang, P. ^{[1
]}

Zuo, H. ^{[1
]}

Li, Z. B. ^{[1
]}

机构：

[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400716, Peoples R China

[2] Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 11期

关键词：

Florfenicol; Prodrug; Synthesis; DMAP; Esterification; PHARMACOKINETICS; CALVES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-soluble prodrug of florfenicol was synthesized by introducing a water-soluble small moiety to the hydroxyl of florfenicol according to I the prodrug design principles. The water-solubility of the prodrug was about 500 times higher than florfenicol and the water soluble prodrug of forfenicol displays high aqueous solubility and is stable in water as well as in organic solvents.

引用

页码：5157 / 5158

页数：2

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