Oxali-titanocene Y:: A potent anticancer drug

被引：51
作者：
Claffey, James [1 ]
Hogan, Megan [1 ]
Mueller-Bunz, Helge [1 ]
Pampillon, Clara [1 ]
Tacke, Matthias [1 ]
机构：
[1] UCD, Conway Inst Biomol & Biomed Res, UCD Sch Chem & Chem Biol, CSCB, Dublin 4, Ireland
来源：
CHEMMEDCHEM | 2008年 / 3卷 / 05期
关键词：
antitumor agents; fulvenes; hydridolithiation; oxalates; titanocenes;
D O I：
10.1002/cmdc.200700302
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In three simple steps the anticancer drug bis-[(p-methoxybenzyl) cyclopentadienyl] titanium(IV) oxalate (oxali-titanocene Y) can be synthesised from commercially available starting materials. Oxali-titanocene Y shows twice the cytotoxicity of cisplatin in pig kidney epithelial (LLC-PK) cells and is the most cytotoxic titanocene known. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：729 / 731
页数：3
相关论文
共 13 条
  • [1] [Anonymous], 1979, Angew. Chem
  • [2] Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo
    Bannon, J. H.
    Fichtner, I.
    O'Neill, A.
    Pampillon, C.
    Sweeney, N. J.
    Strohfeldt, K.
    Watson, R. W.
    Tacke, M.
    Mc Gee, M. M.
    [J]. BRITISH JOURNAL OF CANCER, 2007, 97 (09) : 1234 - 1241
  • [3] Antitumor activity of Titanocene Y against freshly explanted human breast tumor cells and in xenografted MCF-7 tumors in mice
    Beckhove, Philipp
    Oberschmidt, Olaf
    Hanauske, Axel R.
    Pampillon, Clara
    Schirrmacher, Volker
    Sweeney, Nigel J.
    Strohfeldt, Katja
    Tacke, Matthias
    [J]. ANTI-CANCER DRUGS, 2007, 18 (03) : 311 - 315
  • [4] Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice
    Fichtner, Iduna
    Pampillon, Clara
    Sweeney, Nigel J.
    Strohfeldt, Katja
    Tacke, Matthias
    [J]. ANTI-CANCER DRUGS, 2006, 17 (03) : 333 - 336
  • [5] Update of the preclinical situation of anticancer platinum complexes: Novel design strategies and innovative analytical approaches
    Galanski, M
    Jakupec, MA
    Keppler, BK
    [J]. CURRENT MEDICINAL CHEMISTRY, 2005, 12 (18) : 2075 - 2094
  • [6] Tri-n-butyl-phosphane silver(I) complexes with carboxylate-, tropolonate- or N-hydroxyphthalimide building blocks;: Synthesis and their use as spin-on precursors
    Jakob, A
    Schmidt, H
    Walfort, B
    Rheinwald, G
    Frühauf, S
    Schulz, S
    Gessner, T
    Lang, H
    [J]. ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 2005, 631 (6-7): : 1079 - 1086
  • [7] In-vitro anti-tumor activity studies of bridged and unbridged benzyl-substituted titanocenes
    Kelter, G
    Sweeney, NJ
    Strohfeldt, K
    Fiebig, HH
    Tacke, M
    [J]. ANTI-CANCER DRUGS, 2005, 16 (10) : 1091 - 1098
  • [8] TITANOCENE DICHLORIDE - 1ST METALLOCENE WITH CANCEROSTATIC ACTIVITY
    KOPF, H
    KOPFMAIER, P
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1979, 18 (06): : 477 - 478
  • [9] Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells
    O'Connor, K.
    Gill, C.
    Tacke, M.
    Rebmann, F. -J. K.
    Strohfeldt, K.
    Sweeney, N.
    Fitzpatrick, J. M.
    Watson, R. W. G.
    [J]. APOPTOSIS, 2006, 11 (07) : 1205 - 1214
  • [10] Activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-domethylaminophenyl)-ethanediyl] titanium dichloride against tumor colony-forming units
    Oberschmidt, O
    Hanauske, AR
    Rehmann, FJK
    Strohfeldt, K
    Sweeney, N
    Tacke, M
    [J]. ANTI-CANCER DRUGS, 2005, 16 (10) : 1071 - 1073
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