Oxali-titanocene Y:: A potent anticancer drug

被引：51

作者：

Claffey, James ^{[1
]}

Hogan, Megan ^{[1
]}

Mueller-Bunz, Helge ^{[1
]}

Pampillon, Clara ^{[1
]}

Tacke, Matthias ^{[1
]}

机构：

[1] UCD, Conway Inst Biomol & Biomed Res, UCD Sch Chem & Chem Biol, CSCB, Dublin 4, Ireland

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 05期

关键词：

antitumor agents; fulvenes; hydridolithiation; oxalates; titanocenes;

D O I：

10.1002/cmdc.200700302

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In three simple steps the anticancer drug bis-[(p-methoxybenzyl) cyclopentadienyl] titanium(IV) oxalate (oxali-titanocene Y) can be synthesised from commercially available starting materials. Oxali-titanocene Y shows twice the cytotoxicity of cisplatin in pig kidney epithelial (LLC-PK) cells and is the most cytotoxic titanocene known. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：729 / 731

页数：3

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