Synthesis of 4-(1-Phenyl-1H-pyrazol-3-yl)-[1,2,4] triazolo[4,3a] quinoxalines and Their 4-Halogenopyrazolyl Analogs

被引：4
作者：
Atta, Kamal F. M. [1 ]
El Ashry, El Sayed H. [1 ]
机构：
[1] Univ Alexandria, Dept Chem, Fac Sci, Alexandria 21321, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 48卷 / 05期
关键词：
ADENOSINE RECEPTOR ANTAGONISTS; PHARMACOLOGICAL EVALUATION; DERIVATIVES; POTENT; ACID; HETEROCYCLES; LIGANDS; DESIGN; MODE;
D O I：
10.1002/jhet.694
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of {3-[1-(ethoxycarbonyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl]-1-phenyl-1H-pyrazol-5-y1} methyl ethyl oxalate (2), ethyl 4-[5-(acetoxymethyl)-1-phenyl-1H-pyrazol-3-yl]-[1,2,4]triazolo[4,3-a] quioxaline-1-carboxylate (4), [4-halo-1-phenyl-3-(1-phenyl-[1,2,4]triazolo[4,3-a]quioxalin-4-yl)-1Hpyrazol- 5-yl]methyl acetate (11), {4-halo-3-[1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl]-1-phenyl1H- pyraz-ol-5-yl}methyl acetate (13), and [3-([1,2,4]triazolo-[4,3-a]quinoxalin-4-yl)-4-halo-1-phenyl-1H- pyrazol-5-yl]methyl formate (15) was accomplished. The structural investigation of the new compounds is based on chemical and spectroscopic evidences.
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页码：1216 / 1223
页数：8
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