Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

被引：49
作者：
Chen, Yongsheng [1 ]
Wu, Shuodong [1 ]
Tian, Yu [1 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Gen Surg, 36 San Hao St, Shenyang 110004, Liaoning, Peoples R China
来源：
LABORATORY INVESTIGATION | 2018年 / 98卷 / 01期
关键词：
FIBROBLAST GROWTH FACTOR-19; FARNESOID-X-RECEPTOR; FATTY LIVER-DISEASE; BILE-ACIDS; INSULIN-RESISTANCE; WEIGHT-GAIN; GALLSTONE DISEASE; GLUCOSE; TGR5; GALLBLADDER;
D O I：
10.1038/labinvest.2017.95
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cholecystectomy has long been regarded as a safe procedure with no deleterious influence on the body. However, recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, we describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated, including visceral obesity, dyslipidemia, elevated blood pressure, impaired fasting glucose, and insulin resistance. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.
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收藏
页码：7 / 14
页数：8
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