Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

被引：46
作者：
Chen, Yongsheng [1 ]
Wu, Shuodong [1 ]
Tian, Yu [1 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Gen Surg, 36 San Hao St, Shenyang 110004, Liaoning, Peoples R China
来源：
LABORATORY INVESTIGATION | 2018年 / 98卷 / 01期
关键词：
FIBROBLAST GROWTH FACTOR-19; FARNESOID-X-RECEPTOR; FATTY LIVER-DISEASE; BILE-ACIDS; INSULIN-RESISTANCE; WEIGHT-GAIN; GALLSTONE DISEASE; GLUCOSE; TGR5; GALLBLADDER;
D O I：
10.1038/labinvest.2017.95
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cholecystectomy has long been regarded as a safe procedure with no deleterious influence on the body. However, recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, we describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated, including visceral obesity, dyslipidemia, elevated blood pressure, impaired fasting glucose, and insulin resistance. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.
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收藏
页码：7 / 14
页数：8
相关论文
共 64 条
[1]   Impact of treating the metabolic syndrome on chronic kidney disease [J].
Agrawal, Varun ;
Shah, Aashish ;
Rice, Casey ;
Franklin, Barry A. ;
McCullough, Peter A. .
NATURE REVIEWS NEPHROLOGY, 2009, 5 (09) :520-528
[2]   Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].
Alberti, K. G. M. M. ;
Eckel, Robert H. ;
Grundy, Scott M. ;
Zimmet, Paul Z. ;
Cleeman, James I. ;
Donato, Karen A. ;
Fruchart, Jean-Charles ;
James, W. Philip T. ;
Loria, Catherine M. ;
Smith, Sidney C., Jr. .
CIRCULATION, 2009, 120 (16) :1640-1645
[3]   The metabolic syndrome - a new worldwide definition [J].
Alberti, KGMM ;
Zimmet, P ;
Shaw, J .
LANCET, 2005, 366 (9491) :1059-1062
[4]   Weight gain after laparoscopic cholecystectomy [J].
Ali, RB ;
Cahill, RA ;
Watson, RGK .
IRISH JOURNAL OF MEDICAL SCIENCE, 2004, 173 (01) :9-12
[5]   Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice [J].
Amigo, Ludwig ;
Husche, Constanze ;
Zanlungo, Silvana ;
Luetjohann, Dieter ;
Arrese, Marco ;
Miquel, Juan F. ;
Rigotti, Attilio ;
Nervi, Flavio .
LIVER INTERNATIONAL, 2011, 31 (01) :52-64
[6]   The metabolic syndrome is associated with complicated gallstone disease [J].
Ata, Naim ;
Kucukazman, Metin ;
Yavuz, Bunyamin ;
Bulus, Hakan ;
Dal, Kursat ;
Ertugrul, Derun Taner ;
Yalcin, Ahmet Arif ;
Polat, Mehmet ;
Varol, Numan ;
Akin, Kadir Okhan ;
Karabag, Aral ;
Nazligul, Yasar .
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 25 (05) :274-276
[7]   Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19 [J].
Barrera, Francisco ;
Azocar, Lorena ;
Molina, Hector ;
Schalper, Kurt A. ;
Ocares, Marcia ;
Liberona, Jessica ;
Villarroel, Luis ;
Pimentel, Fernando ;
Perez-Ayuso, Rosa M. ;
Nervi, Flavio ;
Groen, Albert K. ;
Miquel, Juan F. .
ANNALS OF HEPATOLOGY, 2015, 14 (05) :710-721
[8]   Prevalence and Trends of Metabolic Syndrome in the Adult U.S. Population, 1999-2010 [J].
Beltran-Sanchez, Hiram ;
Harhay, Michael O. ;
Harhay, Meera M. ;
McElligott, Sean .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (08) :697-703
[9]   Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis [J].
Bhatnagar, Sushant ;
Damron, Holly A. ;
Hillgartner, F. Bradley .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (15) :10023-10033
[10]   Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract [J].
Bunnett, Nigel W. .
JOURNAL OF PHYSIOLOGY-LONDON, 2014, 592 (14) :2943-2950
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