Frequency-Domain Optical Tomographic Imaging of Arthritic Finger Joints

被引：51

作者：

Hielscher, Andreas H. ^{[1
,2
,3
]}

Kim, Hyun Keol ^{[1
]}

Montejo, Ludguier D. ^{[1
]}

Blaschke, Sabine ^{[4
]}

Netz, Uwe J. ^{[5
,6
]}

Zwaka, Paul A. ^{[7
]}

Illing, Gerd ^{[5
]}

Mueller, Gerhard A. ^{[4
]}

Beuthan, Juergen ^{[6
]}

机构：

[1] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA

[2] Columbia Univ, Dept Radiol, New York, NY 10027 USA

[3] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA

[4] Univ Gottingen, Univ Med Ctr Gottingen, Dept Nephrol & Rheumatol, D-37075 Gottingen, Germany

[5] Laser & Med Technol GmbH Berlin, D-14195 Berlin, Germany

[6] Charite, Dept Med Phys & Laser Med, D-10117 Berlin, Germany

[7] Univ Gottingen, Univ Med Ctr Gottingen, Dept Radiol, D-37075 Gottingen, Germany

来源：

IEEE TRANSACTIONS ON MEDICAL IMAGING | 2011年 / 30卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Computer aided diagnostics; light propagation in tissue; optical tomography; rheumatoid arthritis (RA); RHEUMATOID-ARTHRITIS; PHOTOACOUSTIC TOMOGRAPHY; RHEUMATOLOGY/EUROPEAN LEAGUE; AMERICAN-COLLEGE; DISEASE-ACTIVITY; HAND JOINTS; EQUATION; CLASSIFICATION; CRITERIA; OSTEOARTHRITIS;

D O I：

10.1109/TMI.2011.2135374

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

We are presenting data from the largest clinical trial on optical tomographic imaging of finger joints to date. Overall we evaluated 99 fingers of patients affected by rheumatoid arthritis (RA) and 120 fingers from healthy volunteers. Using frequency-domain imaging techniques we show that sensitivities and specificities of 0.85 and higher can be achieved in detecting RA. This is accomplished by deriving multiple optical parameters from the optical tomographic images and combining them for the statistical analysis. Parameters derived from the scattering coefficient perform slightly better than absorption derived parameters. Furthermore we found that data obtained at 600 MHz leads to better classification results than data obtained at 0 or 300 MHz.

引用

页码：1725 / 1736

页数：12

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