Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug Delivery

被引:51
作者
Lee, Na-Hyun [1 ,2 ,3 ]
You, Sumin [1 ,4 ]
Taghizadeh, Ali [1 ]
Taghizadeh, Mohsen [1 ]
Kim, Hye Sung [1 ,5 ,6 ]
机构
[1] Dankook Univ, Inst Tissue Regenerat Engn, Cheonan 31116, South Korea
[2] Dankook Univ, Dept Nanobiomed Sci, Cheonan 31116, South Korea
[3] Dankook Univ, NBM Global Res Ctr Regenerat Med BK21, Cheonan 31116, South Korea
[4] Dankook Univ, Dept Chem, Cheonan 31116, South Korea
[5] Dankook Univ, Dept Regenerat Dent Med, Coll Dent, Cheonan 31116, South Korea
[6] Dankook Univ, Mechanobiol Dent Med Res Ctr, Cheonan 31116, South Korea
基金
新加坡国家研究基金会;
关键词
cell membrane; nanoparticle; drug delivery; cell membrane engineering; MESOPOROUS SILICA NANOPARTICLES; PHOTODYNAMIC THERAPY; COATED NANOPARTICLES; PHOTOTHERMAL THERAPY; CANCER; VESICLES; DEGRADATION; PEGYLATION; MECHANISM; PLATFORM;
D O I
10.3390/ijms23042223
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell membrane cloaking technique is bioinspired nanotechnology that takes advantage of naturally derived design cues for surface modification of nanoparticles. Unlike modification with synthetic materials, cell membranes can replicate complex physicochemical properties and biomimetic functions of the parent cell source. This technique indeed has the potential to greatly augment existing nanotherapeutic platforms. Here, we provide a comprehensive overview of engineered cell membrane-based nanotherapeutics for targeted drug delivery and biomedical applications and discuss the challenges and opportunities of cell membrane cloaking techniques for clinical translation.
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页数:22
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