Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis

被引：199

作者：

Dattilo, M. ^{[2
]}

Antunes, H. K. M. ^{[2
,3
]}

Medeiros, A. ^{[3
]}

Monico Neto, M. ^{[2
]}

Souza, H. S. ^{[2
]}

Tufik, S. ^{[1
]}

de Mello, M. T. ^{[1
,2
]}

机构：

[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil

[2] CEPE, Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Dept Biociencias, Santos, Brazil

来源：

MEDICAL HYPOTHESES | 2011年 / 77卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

SKELETAL-MUSCLE; PROTEIN-SYNTHESIS; DEPRIVATION; CORTISOL; DIFFERENTIATION; CONSEQUENCES; ACTIVATION; EXPRESSION; MYOSTATIN; PATHWAY;

D O I：

10.1016/j.mehy.2011.04.017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sleep is essential for the cellular, organic and systemic functions of an organism, with its absence being potentially harmful to health and changing feeding behavior, glucose regulation, blood pressure, cognitive processes and some hormonal axes. Among the hormonal changes, there is an increase in cortisol (humans) and corticosterone (rats) secretion, and a reduction in testosterone and Insulin-like Growth Factor 1, favoring the establishment of a highly proteolytic environment. Consequently, we hypothesized that sleep debt decreases the activity of protein synthesis pathways and increases the activity of degradation pathways, favoring the loss of muscle mass and thus hindering muscle recovery after damage induced by exercise, injuries and certain conditions associated with muscle atrophy, such as sarcopenia and cachexia. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：220 / 222

页数：3

共 41 条

[41] REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss [J].

Wu, Yong ;

Zhao, Weidong ;

Zhao, Jingbo ;

Zhang, Yuanfei ;

Qin, Weiping ;

Pan, Jiangping ;

Bauman, William A. ;

Blitzer, Robert D. ;

Cardozo, Christopher .

ENDOCRINOLOGY, 2010, 151 (03) :1050-1059

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