Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

被引：1104
作者：
Presta, M [1 ]
Dell'Era, P [1 ]
Mitola, S [1 ]
Moroni, E [1 ]
Ronca, R [1 ]
Rusnati, M [1 ]
机构：
[1] Univ Brescia, Sch Med, Dept Biomed Sci & Biotechnol, Unit Gen Pathol & Immunol, I-25123 Brescia, Italy
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 02期
关键词：
angiogenesis; endothelium; FGF; FGF receptors; tumor;
D O I：
10.1016/j.cytogfr.2005.01.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins. Their activity is modulated by a variety of free and extracellular matrix-associated molecules. Also, the cross-talk among FGFs, vascular endothelial growth factors (VEGFs), and inflammatory cytokines/chemokines may play a role in the modulation of blood vessel growth in different pathological conditions, including cancer. Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：159 / 178
页数：20
相关论文
共 259 条
[11]   DIFFERENTIAL MODULATION OF CELL PHENOTYPE BY DIFFERENT MOLECULAR-WEIGHT FORMS OF BASIC FIBROBLAST GROWTH-FACTOR - POSSIBLE INTRACELLULAR SIGNALING BY THE HIGH-MOLECULAR-WEIGHT FORMS [J].
BIKFALVI, A ;
KLEIN, S ;
PINTUCCI, G ;
QUARTO, N ;
MIGNATTI, P ;
RIFKIN, DB .
JOURNAL OF CELL BIOLOGY, 1995, 129 (01) :233-243
[12]   Role of tumor-associated gangliosides in cancer progression [J].
Birklé, S ;
Zeng, G ;
Gao, L ;
Yu, RK ;
Aubry, J .
BIOCHIMIE, 2003, 85 (3-4) :455-463
[13]   T-LYMPHOCYTES SYNTHESIZE AND EXPORT HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR, MITOGENS FOR VASCULAR CELLS AND FIBROBLASTS - DIFFERENTIAL PRODUCTION AND RELEASE BY CD4+ AND CD8+ T-CELLS [J].
BLOTNICK, S ;
PEOPLES, GE ;
FREEMAN, MR ;
EBERLEIN, TJ ;
KLAGSBRUN, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) :2890-2894
[14]   Thrombospondin 2, a matricellular protein with diverse functions [J].
Bornstein, P ;
Armstrong, LC ;
Hankenson, KD ;
Kyriakides, TR ;
Yang, ZT .
MATRIX BIOLOGY, 2000, 19 (07) :557-568
[15]   Antiangiogenic properties of fibstatin, an extracellular FGF-2-binding polypeptide [J].
Bossard, C ;
Van den Berghe, L ;
Laurell, H ;
Castano, C ;
Cerutti, M ;
Prats, AC ;
Prats, H .
CANCER RESEARCH, 2004, 64 (20) :7507-7512
[16]   Multimer formation and ligand recognition by the long pentraxin PTX3 - Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component [J].
Bottazzi, B ;
Vouret-Craviari, V ;
Bastone, A ;
De Gioia, L ;
Matteucci, C ;
Peri, G ;
Spreafico, F ;
Pausa, M ;
D'Ettorre, C ;
Gianazza, E ;
Tagliabue, A ;
Salmona, M ;
Tedesco, F ;
Introna, M ;
Mantovani, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) :32817-32823
[17]  
BREVIARIO F, 1992, J BIOL CHEM, V267, P22190
[18]   HISTIDINE-RICH GLYCOPROTEIN AND PLATELET FACTOR-4 MASK HEPARAN-SULFATE PROTEOGLYCANS RECOGNIZED BY ACIDIC AND BASIC FIBROBLAST GROWTH-FACTOR [J].
BROWN, KJ ;
PARISH, CR .
BIOCHEMISTRY, 1994, 33 (46) :13918-13927
[19]  
BRUSTLE O, 1992, ONCOGENE, V7, P1177
[20]   Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2 [J].
Cao, RH ;
Bråkenhielm, E ;
Pawliuk, R ;
Wariaro, D ;
Post, MJ ;
Wahlberg, E ;
Leboulch, P ;
Cao, YH .
NATURE MEDICINE, 2003, 9 (05) :604-613
12345678910