Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

被引：1104

作者：

Presta, M ^{[1
]}

Dell'Era, P ^{[1
]}

Mitola, S ^{[1
]}

Moroni, E ^{[1
]}

Ronca, R ^{[1
]}

Rusnati, M ^{[1
]}

机构：

[1] Univ Brescia, Sch Med, Dept Biomed Sci & Biotechnol, Unit Gen Pathol & Immunol, I-25123 Brescia, Italy

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 02期

关键词：

angiogenesis; endothelium; FGF; FGF receptors; tumor;

D O I：

10.1016/j.cytogfr.2005.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins. Their activity is modulated by a variety of free and extracellular matrix-associated molecules. Also, the cross-talk among FGFs, vascular endothelial growth factors (VEGFs), and inflammatory cytokines/chemokines may play a role in the modulation of blood vessel growth in different pathological conditions, including cancer. Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：159 / 178

页数：20

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