Mesenchymal stem cells for treating autoimmune diseases: The Chinese experience from lab to clinics

被引：7
作者：
Liang, J. [1 ]
Wang, D. [1 ]
Farge, D. [2 ]
Sun, L. [1 ]
机构：
[1] Nanjing Univ, Dept Immunol & Rheumatol, Affiliated Drum Tower Hosp, Med Sch, 321 Zhongshan Rd, CN-210008 Nanjing, Jiangsu, Peoples R China
[2] Paris 7 Diderot Univ, Sorbonne Paris Cite, St Louis Hosp,UMRS 1160, AP HP,Inernal Med & Vasc Dis Unit CIC BT501,Inser, 1,Ave Claude Vellefaux, F-75010 Paris, France
来源：
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE | 2016年 / 64卷 / 02期
关键词：
Autoimmune diseases; Mesenchymal stem cells; Transplantation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MARROW STROMAL CELLS; UMBILICAL-CORD; TRANSPLANTATION; DIFFERENTIATION; PHENOTYPE; PLURIPOTENCY; SCLEROSIS; RESPONSES; INHIBIT;
D O I：
10.1016/j.retram.2016.04.007
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Autoimmune diseases are a group of chronic inflammatory conditions diseases characterized by aberrant activation of the immune system involving either cells or antibodies directed against normal tissues. The current conventional strategies, notably corticosteroids and immunosuppressors, are responsible for high treatment-related morbidity and are still associated with significant disease and treatment-related mortality. Recently, experimental and clinical data has suggested that mesenchymal stem cell transplantation would be a promising therapy strategy for the treatment of autoimmune diseases. This article will review the rationale and Chinese experience of mesenchymal stem cell transplantation in treatment of autoimmune diseases. (C) 2016 Published by Elsevier Masson SAS.
引用
收藏
页码：115 / 120
页数：6
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