Catalepsy induced by the 5-HT1A receptor antagonist WAY 100635 in rats pretreated with the selective serotonin reuptake inhibitor citalopram

被引：3
作者：
Eltayb, A [1 ]
Svensson, TH [1 ]
Ahlenius, S [1 ]
机构：
[1] Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 411卷 / 03期
关键词：
5-HT1A receptors; 5-HT; (5-hydroxytrypytamine; serotonin) reuptake inhibitor; selective; catalepsy; (Rat);
D O I：
10.1016/S0014-2999(00)00924-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Neither a high dose of the selective serotonin reuptake inhibitor citalopram (100 mu mol kg(-1) s.c.), nor the 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperaziny]-N-ethyl]-N-(2-pyridinyl) cyclohexane carboxamide 3HCl (WAY 100635) (0.1-0.4 mu mol kg(-1) s.c.) produced any evidence of catalepsy in adult male rats. When combined with citalopram, however. WAY 100635 produced a dose-dependent, and statistically significant, catalepsy in the inclined grid test. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：275 / 277
页数：3
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