Genotoxicity and inflammatory investigation in mice treated with magnetite nanoparticles surface coated with polyaspartic acid

被引：94
作者：
Sadeghiani, N
Barbosa, LS
Silva, LP
Azevedo, RB
Morais, PC
Lacava, ZGM [1 ]
机构：
[1] Univ Brasilia, Inst Biol, GEM, BR-70910900 Brasilia, DF, Brazil
[2] Univ Brasilia, Inst Fis Nucl Fis Aplicada, BR-70919970 Brasilia, DF, Brazil
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 289卷
关键词：
magnetic fluid; polyaspartic acid; micronucleus test; biocompatibility;
D O I：
10.1016/j.jmmm.2004.11.131
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this study, some biological tests were carried out with a magnetic fluid (MF) sample based on magnetite nanoparticles (MNPs) surface coated with polyaspartic acid (PAMF). The tests were performed from 1 to 30 days after injection of 50 mu L of PAMF in Swiss mice. The PAMF biocompatibility/toxicity was evaluated through cytometry, micronuclei assay, and morphology of several organs. All observed results were time and dose dependent. The data indicate that MNPs surface-treated with polyaspartic acid may be considered as a potential precursor of anticancer drugs. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：466 / 468
页数：3
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