Prognostic factors in idiopathic pulmonary fibrosis in a tunisian cohort

被引：3

作者：

Touil, I ^{[1
]}

Boudawara, N. Keskes ^{[1
]}

Bouchareb, S. ^{[1
]}

Ben Saad, A. ^{[2
]}

Migaou, A. ^{[2
]}

Mhamed, S. Cheikh ^{[2
]}

Fahem, N. ^{[2
]}

Mribah, H. ^{[2
]}

Knani, J. ^{[1
]}

Boussoffara, L. ^{[1
]}

Rouatbi, N. ^{[2
]}

Joobeur, S. ^{[2
]}

机构：

[1] Hop Tahar Sfar Mahdia, Serv Pneumol, Ave Taher SfarVile Mahdia, Mahdia 5100, Tunisia

[2] Hop Fattouma Bourguiba Monastir, Serv Pneumol, Monastir 5000, Tunisia

来源：

REVUE DES MALADIES RESPIRATOIRES | 2021年 / 38卷 / 07期

关键词：

Idiopathic pulmonary fibrosis; Chest computed tomography; Prognosis; Survival; FRENCH PRACTICAL GUIDELINES; MANAGEMENT; DIAGNOSIS; PREDICTION; SURVIVAL; DISEASES;

D O I：

10.1016/j.rmr.2021.04.015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We present data on prognostic factors in a Tunisian cohort of people with Idiopathic pulmonary fibrosis. Introduction. - Idiopathic pulmonary fibrosis (IPF) has a poor prognosis, with a median survival in patients with the condition of only 3 to 5 years. Previous studies have identified a number of prognostic factors in this chronic pulmonary disease. Methods. - We conducted a retrospective study, including patients with idiopathic pulmonary fibrosis (IPF) who were diagnosed at the Pneumology Department of the University Hospital Fattouma-Bourguiba, Monastir, between 1991 and 2014. The aim of this study was to compare clinical, radiological, pulmonary functional predictors of survival in IPF in a Tunisian cohort with those of previous studies. Results. - This study included 126 patients. Their mean age was 66 years, with a male predominance (68.3%). Respiratory function tests revealed a restrictive ventilatory deficit in 72.6% of cases. The median survival of our study population was 22.5 months [6.7-49.5]. In univariate analysis, factors associated with a poor prognosis were: lower baseline values of TLC, FCV and DLco, level of dyspnea assessed by mMRC scale, hypoxemia at diagnosis, the degree of desaturation during exercise, a higher annual decline of FVC and DLco, acute respiratory distress and also the GAP score. In multivariate analysis, independent prognostic factors were: baseline DLco, level of dyspnea, desaturation at exertion and the annual decline of the DLco. Conclusion. - Lower baseline DLco, the level of dyspnea, desaturation on exercise, and annual decline in DLco are all associated with a poor prognosis in IPF. (C) 2021 SPLF. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：681 / 688

页数：8

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