Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

被引：24
作者：
Chelli, Mohamed Hassen [1 ]
Albert, Martine [1 ,2 ]
Ray, Pierre F. [3 ]
Guthauser, Bruno [4 ]
Izard, Vincent [5 ]
Hammoud, Ibrahim [1 ,2 ]
Selva, Jacqueline [1 ,2 ]
Vialard, Francois [1 ,2 ]
机构：
[1] Ctr Hosp Poissy, Dept Reprod Biol & Cytogenet, St Germain En Laye, France
[2] Univ Versailles, EA 2493, St Quentin en Yvelines, France
[3] Ctr Hosp Univ Grenoble, Dept Genet & Procreat, La Tronche, France
[4] Ctr Hosp, Dept Reprod Biol, Dreux, France
[5] Ctr Hosp Bicetre, Dept Urol, Le Kremlin Bicetre, France
来源：
FERTILITY AND STERILITY | 2010年 / 93卷 / 04期
关键词：
FISH; large-headed spermatozoa; normal-head-size spermatozoa; high magnification; IMSI; macrocephalic sperm head syndrome; meiotic division deficiency; POLYPLOID SPERMATOZOA; ICSI; ANEUPLOIDIES; FAILURE;
D O I：
10.1016/j.fertnstert.2008.10.059
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. Design: Case report. Setting: Obstetrics, gynecology, urology, and reproductive biology departments. Patient(s): Two infertile patients with large-headed spermatozoa. Intervention(s): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection. Main Outcome Measure(s): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa. Result(s): Of the six spermatozoa that could be selected, all were haploid but aneuploid. Conclusion(s): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients. (Fertil Steril (R) 2010;93:1347.e1-e5. (C) 2010 by American Society for Reproductive Medicine.)
引用
收藏
页码：1347.e1 / 1347.e5
页数：5
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