Metal-Free Csp3-N Bond Cleavage of Amides Using tert-Butyl Hydroperoxide as Oxidant

被引：12

作者：

Guo, Shengmei ^{[1
]}

Zhu, Zheng ^{[1
]}

Lu, Lin ^{[1
]}

Zhang, Wenbiao ^{[1
]}

Gong, Jiuhan ^{[1
]}

Cai, Hu ^{[1
]}

机构：

[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China

来源：

SYNLETT | 2015年 / 26卷 / 04期

基金：

中国国家自然科学基金;

关键词：

metal-free; C-N bond cleavage; amides; dicarbonyl compounds; oxidation; C-N CLEAVAGE; BRIDGED BIS-1,3-DICARBONYL COMPOUNDS; ONE-POT CONVERSION; CARBON SOURCE; H FUNCTIONALIZATION; CATALYZED CYANATION; AROMATIC NITRILES; AMINES SYNTHESIS; DIRECT AMINATION; N; N-DIMETHYLFORMAMIDE;

D O I：

10.1055/s-0034-1379879

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient protocol for the metal-free C-N bond-cleavage of amides has been developed. The methodology employs iodine as a catalyst to cleave the C(Me)-N bond of dimethylformamide or dimethylacetamide, providing novel access to methylene-bridged bis-1,3-dicarbonyl compounds instead of enol carbamates in the presence of tert-butyl hydroperoxide.

引用

页码：543 / 546

页数：4

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