Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review

被引：25

作者：

Sparic, Radmila ^{[1
,2
]}

Andjic, Mladen ^{[1
]}

Babovic, Ivana ^{[1
,2
]}

Nejkovic, Lazar ^{[2
,3
]}

Mitrovic, Milena ^{[1
,2
]}

Stulic, Jelena ^{[3
]}

Pupovac, Miljan ^{[1
]}

Tinelli, Andrea ^{[4
,5
]}

机构：

[1] Univ Clin Ctr Serbia, Clin Gynecol & Obstet, Koste Todorovica 26, Belgrade 11000, Serbia

[2] Univ Belgrade, Fac Med, Belgrade 11000, Serbia

[3] Clin Gynecol & Obstet Narodni Front, Belgrade 11000, Serbia

[4] Verisdelli Ponti Hosp, Dept Obstet & Gynecol, Via Giuseppina Delli Ponti, I-73020 Scorrano, LE, Italy

[5] Verisdelli Ponti Hosp, CERICSAL Ctr Ric Clin SALentino, Via Giuseppina Delli Ponti, I-73020 Scorrano, LE, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 17期

关键词：

uterine fibroid; leiomyosarcoma; molecular; gene; differential diagnosis; omics; LAPAROSCOPIC MYOMECTOMY; PROLIFERATION; EXPRESSION; SYNDECAN-1; MUTATIONS; LEIOMYOMA; OUTCOMES; GROWTH; TUMORS;

D O I：

10.3390/ijms23179728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uterine fibroids (UFs) are the most common benign tumors of female genital diseases, unlike uterine leiomyosarcoma (LMS), a rare and aggressive uterine cancer. This narrative review aims to discuss the biology and diagnosis of LMS and, at the same time, their differential diagnosis, in order to distinguish the biological and molecular origins. The authors performed a Medline and PubMed search for the years 1990-2022 using a combination of keywords on the topics to highlight the many genes and proteins involved in the pathogenesis of LMS. The mutation of these genes, in addition to the altered expression and functions of their enzymes, are potentially biomarkers of uterine LMS. Thus, the use of this molecular and protein information could favor differential diagnosis and personalized therapy based on the molecular characteristics of LMS tissue, leading to timely diagnoses and potential better outcomes for patients.

引用

页数：14

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