Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

被引：574

作者：

Wu, Ai-Min ^{[1
]}

Bisignano, Catherine ^{[2
]}

James, Spencer L. ^{[6
]}

Abady, Gdiom Gebreheat ^{[7
]}

Abedi, Aidin ^{[8
]}

Abu-Gharbieh, Eman ^{[9
]}

Alhassan, Robert Kaba ^{[10
]}

Alipour, Vahid ^{[11
,12
]}

Arabloo, Jalal ^{[11
]}

Asaad, Malke ^{[15
]}

Asmare, Wondwossen Niguse ^{[16
]}

Awedew, Atalel Fentahun ^{[17
]}

Banach, Maciej ^{[18
,19
]}

Banerjee, Srikanta K. ^{[20
]}

Bijani, Ali ^{[21
]}

Birhanu, Tesega Tesega Mengistu ^{[22
]}

Bolla, Srinivasa Rao ^{[23
]}

Camera, Luis Alberto ^{[24
,25
]}

Chang, Jung-Chen ^{[26
,27
]}

Cho, Daniel Youngwhan ^{[3
]}

Chung, Michael T. ^{[28
]}

Couto, Rosa A. S. ^{[29
]}

Dai, Xiaochen ^{[2
]}

Dandona, Lalit ^{[2
,31
,32
]}

Dandona, Rakhi ^{[2
,4
,31
]}

Farzadfar, Farshad ^{[33
]}

Filip, Irina ^{[35
,36
]}

Fischer, Florian ^{[37
]}

Fomenkov, Artem Alekseevich ^{[38
]}

Gill, Tiffany K. ^{[39
]}

Gupta, Bhawna ^{[40
]}

Haagsma, Juanita A. ^{[41
]}

Haj-Mirzaian, Arvin ^{[34
,42
]}

Hamidi, Samer ^{[43
]}

Hay, Simon, I ^{[2
,4
]}

Ilic, Irena M. ^{[44
]}

Ilic, Milena D. ^{[45
]}

Ivers, Rebecca Q. ^{[46
]}

Jurisson, Mikk ^{[47
]}

Kalhor, Rohollah ^{[48
,49
]}

Kanchan, Tanuj ^{[50
]}

Kavetskyy, Taras ^{[51
,52
]}

Khalilov, Rovshan ^{[53
,54
]}

Khan, Ejaz Ahmad ^{[55
]}

Khan, Maseer ^{[56
]}

Kneib, Cameron J. ^{[3
]}

Krishnamoorthy, Vijay ^{[5
,57
]}

Kumar, G. Anil ^{[31
]}

Kumar, Narinder ^{[58
]}

Lalloo, Ratilal ^{[59
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Zhejiang Prov Key Lab Orthopaed, Dept Orthopaed, Wenzhou 325027, Peoples R China

[2] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, MD USA

[3] Univ Washington, Div Plast Surg, Seattle, WA USA

[4] Univ Washington, Sch Med, Dept Hlth Metr Sci, Seattle, WA USA

[5] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA

[6] Genentech Inc, Personalized Healthcare, 460 Point San Bruno Blvd, San Francisco, CA 94080 USA

[7] Adigrat Univ, Dept Nursing, Adigrat, Ethiopia

[8] Univ Southern Calif, Dept Orthopaed Surg, Los Angeles, CA 90007 USA

[9] Univ Sharjah, Dept Clin Sci, Sharjah, U Arab Emirates

[10] Univ Hlth & Allied Sci, Inst Hlth Res, Ho, Ghana

[11] Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran

[12] Iran Univ Med Sci, Dept Hlth Econ, Tehran, Iran

[13] Iran Univ Med Sci, Plast Surg Dept, Tehran, Iran

[14] Iran Univ Med Sci, Sch Med, Tehran, Iran

[15] Univ Texas Houston, Dept Plast Surg, Houston, TX USA

[16] MizanTepi Univ, Dept Nursing, Mizan Teferi, Ethiopia

[17] Addis Ababa Univ, Dept Surg, Addis Ababa, Ethiopia

[18] Med Univ Lodz, Dept Hypertens, Lodz, Poland

[19] Polish Mothers Mem Hosp Res Inst, Lodz, Poland

[20] Walden Univ, Sch Hlth Sci, Minneapolis, MN USA

[21] Babol Univ Med Sci, Social Determinants Hlth Res Ctr, Babol, Iran

[22] Amhara Publ Hlth Inst, Planning Monitoring & Evaluat Directorate, Bahir Dar, Ethiopia

[23] Nazarbayev Univ, Dept Biomed Sci, Nur Sultan City, Kazakhstan

[24] Hosp Italiano Buenos Aires, Internal Med Dept, Buenos Aires, DF, Argentina

[25] Argentine Soc Med, Board Directors, Buenos Aires, DF, Argentina

[26] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

[27] Natl Taiwan Univ Hosp, Dept Nursing, Taipei, Taiwan

[28] Wayne State Univ, Dept Otolaryngol, Detroit, MI 48201 USA

[29] Univ Porto, Dept Chem Sci, Porto, Portugal

[30] Univ Porto, Dept Chem, Porto, Portugal

[31] Publ Hlth Fdn India, Gurugram, India

[32] Indian Council Med Res, New Delhi, India

[33] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Tehran, Iran

[34] Univ Tehran Med Sci, Dept Pharmacol, Tehran, Iran

[35] Kaiser Permanente, Psychiat Dept, Fontana, CA USA

[36] AT Still Univ, Sch Hlth Sci, Mesa, AZ USA

[37] Ravensburg Weingarten Univ Appl Sci, Inst Gerontol Hlth Serv & Nursing Res, Weingarten, Germany

[38] KA Timiryazev Inst Plant Physiol, Dept Cell Biol & Biotechnol, Moscow, Russia

[39] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia

[40] Torrens Univ, Dept Publ Hlth, Melbourne, Vic, Australia

[41] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands

[42] Shahid Beheshti Univ Med Sci, Obes Res Ctr, Tehran, Iran

[43] Hamdan Bin Mohammed Smart Univ, Sch Hlth & Environm Studies, Dubai, U Arab Emirates

[44] Univ Belgrade, Fac Med, Belgrade, Serbia

[45] Univ Kragujevac, Dept Epidemiol, Kragujevac, Serbia

[46] Univ New South Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia

[47] Univ Tartu, Inst Family Med & Publ Hlth, Tartu, Estonia

[48] Qazvin Univ Med Sci, Inst Prevent Noncommunicable Dis, Qazvin, Iran

[49] Qazvin Univ Med Sci, Hlth Serv Management Dept, Qazvin, Iran

[50] All India Inst Med Sci, Dept Forens Med & Toxicol, Jodhpur, Rajasthan, India

来源：

LANCET HEALTHY LONGEVITY | 2021年 / 2卷 / 09期

关键词：

EXCESS MORTALITY; UNITED-STATES; HIP FRACTURE; EPIDEMIOLOGY; COSTS; INJURY; OSTEOPOROSIS; NONUNION; LIFE;

D O I：

10.1016/S2666-7568(21)00172-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background Bone fractures are a global public health issue; however, to date, no comprehensive study of their incidence and burden has been done. We aimed to measure the global, regional, and national incidence, prevalence, and years lived with disability (YLDs) of fractures from 1990 to 2019. Methods Using the framework of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we compared numbers and age-standardised rates of global incidence, prevalence, and YLDs of fractures across the 21 GBD regions and 204 countries and territories, by age, sex, and year, from 1990 to 2019. We report estimates with 95% uncertainty intervals (UIs). Findings Globally, in 2019, there were 178 million (95% UI 162-196) new fractures (an increase of 33.4% [30.1-37.0] since 1990), 455 million (428-484) prevalent cases of acute or long-term symptoms of a fracture (an increase of 70.1% [67.5-72.5] since 1990), and 25.8 million (17.8-35.8) YLDs (an increase of 65.3% [62.4-68.0] since 1990). The age-standardised rates of fractures in 2019 were 2296.2 incident cases (2091.1-2529.5) per 100 000 population (a decrease of 9.6% [8.1-11.1] since 1990), 5614.3 prevalent cases (5286.1-5977.5) per 100 000 population (a decrease of 6.7% [5.7-7.6] since 1990), and 319.0 YLDs (220.1-442.5) per 100 000 population (a decrease of 8.4% [7.2-9.5] since 1990). Lower leg fractures of the patella, tibia or fibula, or ankle were the most common and burdensome fracture in 2019, with an age-standardised incidence rate of 419.9 cases (345.8-512.0) per 100 000 population and an age-standardised rate of YLDs of 190.4 (125.0-276.9) per 100 000 population. In 2019, age-specific rates of fracture incidence were highest in the oldest age groups, with, for instance, 15 381.5 incident cases (11 245.3-20 651.9) per 100 000 population in those aged 95 years and older. Interpretation The global age-standardised rates of incidence, prevalence, and YLDs for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially. Older people have a particularly high risk of fractures, and more widespread injury-prevention efforts and access to screening and treatment of osteoporosis for older individuals should help to reduce the overall burden. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.

引用

页码：E580 / E592

页数：13

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