Cobalt(III)-Catalyzed Synthesis of Fused Quinazolinones by C-H/N-H Annulation of 2-Arylquinazolinones with Alkynes

被引：29
作者：
Kumaran, Subramani [1 ]
Parthasarathy, Kanniyappan [1 ]
机构：
[1] Univ Madras, Dept Organ Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 07期
关键词：
C-H activation; Oxidative annulation; Co catalyst; 2-Arylquinazolinones; Alkynes; CATALYZED OXIDATIVE ANNULATION; REDOX-NEUTRAL SYNTHESIS; ONE-POT SYNTHESIS; BOND ACTIVATION; 2,3-DISUBSTITUTED QUINAZOLINONES; ISOQUINOLINIUM SALTS; TERMINAL ALKYNES; COBALT; CYCLIZATION; ACCESS;
D O I：
10.1002/ejoc.201901763
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and efficient Co-III-catalyzed cyclization of 2-arylquinazolinones with alkynes is described. The electron donating as well as withdrawing groups and also halide substituted quinazolinones are compatible with this reaction. This catalytic reaction is highly regioselective with unsymmetrical alkynes. A possible mechanism, involves a formation of five-membered metallacycle I by metal-catalyzed aromatic C-H bond activation, alkyne insertion, seven-membered metallacycle intermediates followed by reductive elimination to give a final product.
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页码：866 / 869
页数：4
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