Amlodipine overdose causes prolonged calcium channel blocker toxicity

被引：34

作者：

Adams, BD ^{[1
]}

Browne, WT ^{[1
]}

机构：

[1] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA 30905 USA

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 1998年 / 16卷 / 05期

关键词：

amlodipine; calcium channel blockers; overdose; Swan-Ganz catheterization; glucagon; calcium; lactic acidosis;

D O I：

10.1016/S0735-6757(98)90011-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Amlodipine is a relatively new agent that has the longest half-life of all calcium channel blockers. This report describes a severe overdose that resulted in prolonged and severe hemodynamic compromise for up to 10 days, but responded to aggressive therapy with calcium, glucagon, and other vasoactive medicines. This is a US government work. There are no restrictions on its use.

引用

页码：527 / 528

页数：2

共 11 条

[1] AN OVERVIEW OF THE PHARMACOKINETICS AND PHARMACODYNAMICS OF AMLODIPINE IN ELDERLY PERSONS WITH SYSTEMIC HYPERTENSION [J].

ABERNETHY, DR .

AMERICAN JOURNAL OF CARDIOLOGY, 1994, 73 (03) :A10-A17

[2] UNIQUE PHARMACOLOGICAL PROPERTIES OF AMLODIPINE [J].

BURGES, R ;

MOISEY, D .

AMERICAN JOURNAL OF CARDIOLOGY, 1994, 73 (03) :A2-A9

[3] VERAPAMIL INTOXICATION - A LITERATURE-REVIEW OF OVERDOSES AND DISCUSSION OF THERAPEUTIC OPTIONS [J].

HOFER, CA ;

SMITH, JK ;

TENHOLDER, MF .

AMERICAN JOURNAL OF MEDICINE, 1993, 95 (04) :431-438

[4] CALCIUM-CHANNEL BLOCKING DRUG OVERDOSE - AN AUSTRALIAN SERIES [J].

HOWARTH, DM ;

DAWSON, AH ;

SMITH, AJ ;

BUCKLEY, N ;

WHYTE, IM .

HUMAN & EXPERIMENTAL TOXICOLOGY, 1994, 13 (03) :161-166

[5] FATAL INTOXICATION WITH AMLODIPINE [J].

KOCH, AR ;

VOGELAERS, DP ;

DECRUYENAERE, JM ;

CALLENS, B ;

VERSTRAETE, A ;

BUYLAERT, WA .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1995, 33 (03) :253-256

[6]

LING LJ, 1996, EMERGENCY MED COMPRE, P803

[7]

LIP GYH, 1995, J HUM HYPERTENS, V9, P155

[8] 1994 ANNUAL-REPORT OF THE AMERICAN-ASSOCIATION-OF-POISON-CONTROL-CENTERS TOXIC EXPOSURE SURVEILLANCE SYSTEM [J].

LITOVITZ, TL ;

FELBERG, L ;

SOLOWAY, RA ;

FORD, M ;

GELLER, R .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 1995, 13 (05) :551-597

[9] 1995 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System [J].

Litovitz, TL ;

Felberg, L ;

White, S ;

KleinSchwartz, W .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 1996, 14 (05) :487-537

[10] CALCIUM-CHANNEL BLOCKER OVERDOSE [J].

PROANO, L ;

CHIANG, WK ;

WANG, RY .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 1995, 13 (04) :444-450

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