TRANSLATION An O-GlcNAc stamp of approval

被引：3

作者：

Powers, Evan T. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 05期

关键词：

COTRANSLATIONAL UBIQUITINATION; QUALITY-CONTROL; PROTEINS; RIBOSOME;

D O I：

10.1038/nchembio.1777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytosolic proteins can be modified cotranslationally by the installation of O-GlcNAc groups onto serine and threonine residues. This modification suppresses cotranslational ubiquitination and stabilizes proteins against proteasomal degradation.

引用

页码：307 / 308

页数：3

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Zhu Y., 2015, NAT CHEM BIOL, DOI [10.1038/nchembio.1774, DOI 10.1038/NCHEMBIO.1774]

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