Copper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to (E)-β-Sulfonyl Enones

被引：3

作者：

Chen, Rongxiang ^{[1
]}

Li, Shaozhu ^{[1
]}

Zhang, Jinju ^{[1
]}

Cao, Jing ^{[1
]}

Wang, Kai-Kai ^{[1
]}

Meng, Tuanjie ^{[2
]}

Liu, Lantao ^{[2
]}

机构：

[1] Xinxiang Univ, Sch Pharm, Xinxiang 453003, Peoples R China

[2] Shangqiu Normal Univ, Coll Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 19期

基金：

中国国家自然科学基金;

关键词：

VINYL SULFONES; BIOLOGICAL-ACTIVITY; ACRYLAMIDES; INHIBITORS; CHEMISTRY;

D O I：

10.1021/acs.joc.2c01192

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed sulfonylation of alkynyl imines with sulfonyl hydrazides has been developed, which exhibited excellent regio- and stereoselectivity and furnished a series of (E)-beta-sulfonyl enones in moderate to good yields. Mechanistic studies suggest that this strategy goes through a radical process.

引用

页码：13322 / 13330

页数：9

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