Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles

被引：70

作者：

Dong, Qi ^{[1
,2
,3
]}

Liu, Xue ^{[1
,2
]}

Cheng, Ke ^{[3
]}

Sheng, Jiahao ^{[3
]}

Kong, Jing ^{[3
]}

Liu, Tingjiao ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Stomatol Hosp, Dept Basic Sci Stomatol, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai, Peoples R China

[3] Dalian Med Univ, Sch Stomatol, Dept Oral Pathol, Dalian, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

pre-metastatic niche (PMN); extracellular vesicles (EVs); vascular permeability; extracellular matrix (ECM); bone marrow-derived cells (BMDCs); immunosuppression; PREMETASTATIC NICHE; PROGENITOR CELLS; CANCER EXOSOMES; MICROVESICLES; RECRUITMENT; METABOLISM; MEDIATORS; INITIATE; RNAS;

D O I：

10.3389/fcell.2021.733627

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Primary tumors selectively modify the microenvironment of distant organs such as the lung, liver, brain, bone marrow, and lymph nodes to facilitate metastasis. This supportive metastatic microenvironment in distant organs was termed the pre-metastatic niche (PMN) that is characterized by increased vascular permeability, extracellular matrix remodeling, bone marrow-derived cells recruitment, angiogenesis, and immunosuppression. Extracellular vesicles (EVs) are a group of cell-derived membranous structures that carry various functional molecules. EVs play a critical role in PMN formation by delivering their cargos to recipient cells in target organs. We provide an overview of the characteristics of the PMN in different organs promoted by cancer EVs and the underlying mechanisms in this review.

引用

页数：8

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