Synthesis of Tetrahydrobiphenylene via Pd(0)-Catalyzed C(sp2)-H Functionalization

被引：0
|
作者：
Tsukano, Chihiro [1 ]
Suetsugu, Satoshi [1 ]
Muto, Nobusuke [1 ]
Takemoto, Yoshiji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2017年 / 65卷 / 12期
基金：
日本学术振兴会;
关键词：
C-H functionalization; tetrahydrobiphenylene; palladium; BENZYLIC C(SP(3))-H FUNCTIONALIZATION; H BOND FUNCTIONALIZATIONS; CONCISE SYNTHESIS; ISOCYANIDE INSERTION; ANTITUMOR AGENTS; ACTIVATION; DERIVATIVES; BENZOCYCLOBUTENES; BIPHENYLENE; CHLORIDES;
D O I：
10.1248/cpb.c17-00737
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Tetrahydrobiphenylene consists of cyclobutene fused with benzene and cyclohexene rings. In this paper, a direct method for synthesizing tetrahydrobiphenylenes based on a palladium (Pd)(0)-catalyzed C(sp(2))-H functionalization was investigated. The developed method was applied to the synthesis of several tetrahydrobiphenylenes having an oxygen functionality at the ring juncture. The derivatization of a tetrahydrobiphenylene is also reported.
引用
收藏
页码：1167 / 1174
页数：8
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